AURKC (aurora kinase C)

2007-02-01  

Identity

HGNC
LOCATION
19q13.43
LOCUSID
ALIAS
AIE2,AIK3,ARK3,AurC,HEL-S-90,SPGF5,STK13,aurora-C
FUSION GENES

Other Information

Locus ID:

NCBI: 6795
MIM: 603495
HGNC: 11391
Ensembl: ENSG00000105146

Variants:

dbSNP: 6795
ClinVar: 6795
TCGA: ENSG00000105146
COSMIC: AURKC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105146ENST00000302804Q9UQB9
ENSG00000105146ENST00000415300Q9UQB9
ENSG00000105146ENST00000448930A0A0A0MSY3
ENSG00000105146ENST00000594599M0QYK8
ENSG00000105146ENST00000596375B4DXA6
ENSG00000105146ENST00000598785Q9UQB9
ENSG00000105146ENST00000599062Q5Y191
ENSG00000105146ENST00000601799M0QX60

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
246326032015The aurora kinases in cell cycle and leukemia.74
154996542004Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.64
174357572007Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.61
153160252004Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.32
197137632009Aurora-C kinase supports mitotic progression in the absence of Aurora-B.30
159387192005Aurora C is directly associated with Survivin and required for cytokinesis.28
220462982011Overexpression of active Aurora-C kinase results in cell transformation and tumour formation.27
191476832009The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population.24
191476832009The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population.24
196496322010SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.23

Citation

Dessen P

AURKC (aurora kinase C)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46007/aurkc