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AXIN1 (axin 1)

Identity

Other namesAXIN
MGC52315
HGNC (Hugo) AXIN1
Location 16p13.3
Location_base_pair Starts at 277441 and ends at 342465 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AXIN1   903
Entrez_Gene (NCBI)AXIN1  8312  axin 1
Cards
GeneCards (Weizmann)AXIN1
Ensembl (Hinxton)ENSG00000103126 [Gene_View]  AXIN1 [Vega]
AceView (NCBI)AXIN1
Genatlas (Paris)AXIN1
euGene (Indiana)8312
SOURCE (Stanford)NM_003502 NM_181050
Gene Expression (Array Express) ENSG00000103126
Genomic and cartography
GoldenPath (UCSC)AXIN1  -  16p13.3   chr16:277441-342465 -  16p13.3   [Description]    (hg18-March_2006)
EnsemblAXIN1 - 16p13.3 [CytoView]
Mapping of homologs : NCBIAXIN1 [Mapview]
OMIM114550   603816   607864   
Gene and transcription
Gene : Genbank (Entrez)AB208876 AF009674 BC017447 BC035872 BC044648
Reference sequence (RefSeq transcript) :SRSNM_003502 NM_181050
Reference transcript : EntrezNM_003502 NM_181050
RefSeq genomic : SRSAC_000059 AC_000148 NC_000016 NG_012267 NT_010393 NW_001838339 NW_926018
RefSeq genomic : EntrezAC_000059 AC_000148 NC_000016 NG_012267 NT_010393 NW_001838339 NW_926018
Consensus coding sequences : CCDS NCBIAXIN1
Cluster EST : UnigeneHs.592082 [ SRS ] Hs.592082 [ NCBI ]
Alternative Splicing : Fast-db (Paris)419
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtO15169 (SRS) O15169 (Expasy) O15169 (Uniprot)
With graphics : InterProO15169
Splice isoforms : VarSplice FASTAO15169(VarSplice FASTA)
Domaine pattern : Prosite (SRS)DIX (PS50841)    RGS (PS50132)   
Domain pattern : Prosite (Expaxy)DIX (PS50841)    RGS (PS50132)   
Domains : Interpro (SRS)Axin_b-cat_bd    DIX    Regulat_G_prot_signal    Regulat_G_prot_signal_superfam   
Domains : Interpro (EBI)Axin_b-cat_bd    DIX    Regulat_G_prot_signal    Regulat_G_prot_signal_superfam   
Related proteins : CluSTrO15169
Domain families : Pfam SRSAxin_b-cat_bind (PF08833)    DIX (PF00778)    RGS (PF00615)   
Domain families : Pfam SangerAxin_b-cat_bind (PF08833)    DIX (PF00778)    RGS (PF00615)   
Domain families : Pfam NCBIpfam08833    pfam00778    pfam00615   
Domain families : Smart EMBLDAX (SM00021)  RGS (SM00315)  
Blocks (Seattle)O15169
Crystal structure of protein : PDB SRS1DK8    1EMU    1O9U   
Crystal structure of protein : PDBSum1DK8    1EMU    1O9U   
Crystal structure of protein : IMB1DK8    1EMU    1O9U   
Crystal structure of protein : PDB RSDB1DK8    1EMU    1O9U   
HPRD04819
Protein Interaction databases
DIP (DOE-UCLA)O15169
IntAct (EBI)O15169
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIAXIN1
SNP : GeneSNP UtahAXIN1
SNP : HGBaseAXIN1
Genetic variants : HAPMAPAXIN1
Somatic Mutations in Cancer : COSMICAXIN1 
Mutations and Diseases : HGMDAXIN1
Hereditary diseases : OMIM114550    603816    607864   
Hereditary diseases : GENETests114550    603816    607864   
Diseases : Genetic AssociationAXIN1
General knowledge
Homologs : HomoloGeneAXIN1
Homology/Alignments : Family Browser UCSCAXIN1
Phylogenetic Trees/Animal Genes : TreeFamAXIN1
Chemical/Protein Interactions : CTD8312
Keywords Ontology : AmiGOsignal transducer activity  intracellular  nucleus  cytoplasm  cytosol  apoptosis  multicellular organismal development  oocyte axis specification  sensory perception of sound  beta-catenin binding  positive regulation of peptidyl-threonine phosphorylation  cytoplasmic membrane-bounded vesicle  lateral plasma membrane  protein catabolic process  negative regulation of Wnt receptor signaling pathway  negative regulation of Wnt receptor signaling pathway  beta-catenin destruction complex  positive regulation of protein ubiquitination  positive regulation of peptidyl-serine phosphorylation  protein homodimerization activity  positive regulation of JNK cascade  Wnt receptor signaling pathway through beta-catenin  Wnt receptor signaling pathway through beta-catenin  armadillo repeat domain binding  I-SMAD binding  
Keywords Ontology : EGO-EBIsignal transducer activity  intracellular  nucleus  cytoplasm  cytosol  apoptosis  multicellular organismal development  oocyte axis specification  sensory perception of sound  beta-catenin binding  positive regulation of peptidyl-threonine phosphorylation  cytoplasmic membrane-bounded vesicle  lateral plasma membrane  protein catabolic process  negative regulation of Wnt receptor signaling pathway  negative regulation of Wnt receptor signaling pathway  beta-catenin destruction complex  positive regulation of protein ubiquitination  positive regulation of peptidyl-serine phosphorylation  protein homodimerization activity  positive regulation of JNK cascade  Wnt receptor signaling pathway through beta-catenin  Wnt receptor signaling pathway through beta-catenin  armadillo repeat domain binding  I-SMAD binding  
Pathways : BIOCARTAALK in cardiac myocytes [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    Multi-step Regulation of Transcription by Pitx2 [Genes]    Presenilin action in Notch and Wnt signaling [Genes]    WNT Signaling Pathway [Genes]   
Pathways : KEGGWnt signaling pathwayColorectal cancer
Other databases
Probes
Probes : ImagenesAXIN1 Related clones (RZPD - Berlin)
Literature
PubMed94 Pubmed reference(s) in Entrez
PubGeneAXIN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:43:24 CET 2010
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