B3GNT2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2)

2007-02-01  

Identity

HGNC
LOCATION
2p15
LOCUSID
ALIAS
3-Gn-T1,3-Gn-T2,B3GN-T2,B3GNT,B3GNT-2,B3GNT1,BETA3GNT,BGNT2,BGnT-2,beta-1,beta3Gn-T1,beta3Gn-T2
FUSION GENES

Other Information

Locus ID:

NCBI: 10678
MIM: 605581
HGNC: 15629
Ensembl: ENSG00000170340

Variants:

dbSNP: 10678
ClinVar: 10678
TCGA: ENSG00000170340
COSMIC: B3GNT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170340ENST00000301998Q9NY97
ENSG00000170340ENST00000405767Q9NY97

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - keratan sulfateKEGGko00533
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosaminoglycan biosynthesis - keratan sulfateKEGGhsa00533
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188269412008Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.15
270048492016Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.11
128557032003Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins.10
146869312004Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans.7
145558422004Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue.6
275084112016Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).6
249989222014Differential expression patterns of N-acetylglucosaminyl transferases and polylactosamines in uterine lesions.4
155603722004Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase.0
256051932014B3GNT2, a polylactosamine synthase, regulates glycosylation of EGFR in H7721 human hepatocellular carcinoma cells.0

Citation

Dessen P

B3GNT2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46147/b3gnt2