Identity
HGNC
LOCATION
21q22.2
LOCUSID
ALIAS
AEPLC,ALP56,ASP1,ASP21,BAE2,CDA13,CEAP1,DRAP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25825
MIM: 605668
HGNC: 934
Ensembl: ENSG00000182240
Variants:
dbSNP: 25825
ClinVar: 25825
TCGA: ENSG00000182240
COSMIC: BACE2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000182240 | ENST00000328735 | Q9Y5Z0 |
| ENSG00000182240 | ENST00000330333 | Q9Y5Z0 |
| ENSG00000182240 | ENST00000347667 | Q9Y5Z0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Alzheimer's disease | KEGG | ko05010 |
| Alzheimer's disease | KEGG | hsa05010 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37547981 | 2023 | BACE2 deficiency impairs expression and function of endothelial nitric oxide synthase in brain endothelial cells. | 1 |
| 37547981 | 2023 | BACE2 deficiency impairs expression and function of endothelial nitric oxide synthase in brain endothelial cells. | 1 |
| 32647257 | 2021 | Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain. | 49 |
| 33413577 | 2021 | Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells. | 17 |
| 33601055 | 2021 | m(6)A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma. | 9 |
| 32647257 | 2021 | Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain. | 49 |
| 33413577 | 2021 | Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells. | 17 |
| 33601055 | 2021 | m(6)A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma. | 9 |
| 31856384 | 2020 | TGFβ1-induced beta-site APP-cleaving enzyme 2 upregulation promotes tumorigenesis through the NF-κB signalling pathway in human gliomas. | 12 |
| 32160867 | 2020 | BACE2 degradation is mediated by both the proteasome and lysosome pathways. | 7 |
| 32566665 | 2020 | RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation. | 1 |
| 31856384 | 2020 | TGFβ1-induced beta-site APP-cleaving enzyme 2 upregulation promotes tumorigenesis through the NF-κB signalling pathway in human gliomas. | 12 |
| 32160867 | 2020 | BACE2 degradation is mediated by both the proteasome and lysosome pathways. | 7 |
| 32566665 | 2020 | RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation. | 1 |
| 31270419 | 2019 | Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer's Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers. | 10 |
Citation
Dessen P
BACE2 (beta-secretase 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45519/bace2
