BACH1 (BTB domain and CNC homolog 1)

2008-01-01  

Identity

HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
BACH-1,BTBD24
FUSION GENES

Other Information

Locus ID:

NCBI: 571
MIM: 602751
HGNC: 935
Ensembl: ENSG00000156273

Variants:

dbSNP: 571
ClinVar: 571
TCGA: ENSG00000156273
COSMIC: BACH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156273ENST00000286800O14867
ENSG00000156273ENST00000399921O14867
ENSG00000156273ENST00000422809H7C4B6
ENSG00000156273ENST00000435072C9IYH8
ENSG00000156273ENST00000447177C9JMP6
ENSG00000156273ENST00000451655C9IYR0
ENSG00000156273ENST00000468059M0QZP0
ENSG00000156273ENST00000546469F8VZL7
ENSG00000156273ENST00000547141F8VZL7
ENSG00000156273ENST00000548219F8VZL7
ENSG00000156273ENST00000548467F8VZL7
ENSG00000156273ENST00000550131F8VZL7

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA166119041drug-induced liver injuryDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA450112isoniazidChemicalClinicalAnnotationassociatedPD22341855, 29036176

References

Pubmed IDYearTitleCitations
178814342007Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155.230
201277962010MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins.70
170652272006Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin.61
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
125115712003Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.58
146606362004Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.47
226989952012The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes.43
243958012014Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.43
240354982013Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.42

Citation

Dessen P

BACH1 (BTB domain and CNC homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49965/bach1