BATF (basic leucine zipper ATF-like transcription factor)

2007-04-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
B-ATF,BATF1,SFA-2,SFA2
FUSION GENES

Other Information

Locus ID:

NCBI: 10538
MIM: 612476
HGNC: 958
Ensembl: ENSG00000156127

Variants:

dbSNP: 10538
ClinVar: 10538
TCGA: ENSG00000156127
COSMIC: BATF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156127ENST00000286639Q16520
ENSG00000156127ENST00000555504G3V266

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
208902912010Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.176
242164822013Th9 cell development requires a BATF-regulated transcriptional network.65
255404162015Epstein-Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexes.26
127195942003EBNA2 and activated Notch induce expression of BATF.20
125942652003BATF transgenic mice reveal a role for activator protein-1 in NKT cell development.17
271477072017Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction.14
242902792014The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma.13
128095532003Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation.11
254917722014Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorγT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung.7
293768892018BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease.7

Citation

Dessen P

BATF (basic leucine zipper ATF-like transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47196/batf