BAZ1B (bromodomain adjacent to zinc finger domain 1B)

2010-08-01 Affiliation

Identity

HGNC

BAZ1B

LOCATION

7q11.23

LOCUSID

9031

ALIAS

WBSCR10,WBSCR9,WSTF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9031
MIM: 605681
HGNC: 961
Ensembl: ENSG00000009954

Variants:

dbSNP: 9031
ClinVar: 9031
TCGA: ENSG00000009954
COSMIC: BAZ1B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000009954	ENST00000339594	Q9UIG0
ENSG00000009954	ENST00000404251	Q9UIG0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
DNA Repair	REACTOME	R-HSA-73894
DNA Double-Strand Break Repair	REACTOME	R-HSA-5693532
DNA Double Strand Break Response	REACTOME	R-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	REACTOME	R-HSA-5693565
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19092802	2009	WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.	157
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16514417	2006	The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.	56
16603771	2006	The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.	50
19656773	2009	A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.	25
23319141	2013	The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components.	20
21326359	2011	WSTF does it all: a multifunctional protein in transcription, repair, and replication.	19
20580033	2010	Replication of recently described type 2 diabetes gene variants in a South Indian population.	16
27449264	2016	WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways.	14
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11

Citation

Dessen P

BAZ1B (bromodomain adjacent to zinc finger domain 1B)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51570/baz1b