BAZ2A (bromodomain adjacent to zinc finger domain 2A)

2013-06-01 Affiliation

Identity

HGNC

BAZ2A

LOCATION

12q13.3

LOCUSID

11176

ALIAS

TIP5,WALp3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 11176
MIM: 605682
HGNC: 962
Ensembl: ENSG00000076108

Variants:

dbSNP: 11176
ClinVar: 11176
TCGA: ENSG00000076108
COSMIC: BAZ2A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000076108	ENST00000379441	J3KPG5
ENSG00000076108	ENST00000546695	F8VWQ3
ENSG00000076108	ENST00000547453	H0YHL2
ENSG00000076108	ENST00000547650	H0YII3
ENSG00000076108	ENST00000549506	F8W053
ENSG00000076108	ENST00000549787	A0A0C4DGI9
ENSG00000076108	ENST00000549884	F8VU39
ENSG00000076108	ENST00000551812	Q9UIF9
ENSG00000076108	ENST00000551996	H0YHQ7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
Negative epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250941
NoRC negatively regulates rRNA expression	REACTOME	R-HSA-427413

References

Pubmed ID	Year	Title	Citations
25485837	2015	BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.	40
19578370	2009	Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.	39
25479748	2014	lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs.	35
25216700	2015	Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.	20
25533489	2015	Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.	19
17672918	2007	Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.	17
28341809	2017	Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.	10
26100909	2015	BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.	9
25916849	2015	A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.	7
29620186	2018	The transcription factor 7 like 2‑binding protein TIP5 activates β‑catenin/transcription factor signaling in hepatocellular carcinoma.	1

Citation

Dessen P

BAZ2A (bromodomain adjacent to zinc finger domain 2A)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53416/baz2a