BCAP31 (B cell receptor associated protein 31)

2008-08-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
6C6-AG,BAP31,CDM,DDCH,DXS1357E
FUSION GENES

Other Information

Locus ID:

NCBI: 10134
MIM: 300398
HGNC: 16695
Ensembl: ENSG00000185825

Variants:

dbSNP: 10134
ClinVar: 10134
TCGA: ENSG00000185825
COSMIC: BCAP31

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185825ENST00000345046P51572
ENSG00000185825ENST00000416815C9JSP1
ENSG00000185825ENST00000423827C9JMD7
ENSG00000185825ENST00000429550C9JQ75
ENSG00000185825ENST00000430088C9JM14
ENSG00000185825ENST00000442093C9J0M4
ENSG00000185825ENST00000458587P51572
ENSG00000185825ENST00000645377A0A2R8Y5M6
ENSG00000185825ENST00000647529P51572

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126686602003Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol.162
211839552011Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.120
219470792011BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol.73
185557832008BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex.62
152542272004Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death.49
186848162008Bap31 is a novel target of the human papillomavirus E5 protein.33
182875382008Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation.30
168584272007Calnexin-dependent regulation of tunicamycin-induced apoptosis in breast carcinoma MCF-7 cells.28
170565462006Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules.24
211519972010Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.23

Citation

Dessen P

BCAP31 (B cell receptor associated protein 31)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50285/bcap31