Identity
HGNC
LOCATION
14q32.2
LOCUSID
ALIAS
B2R,BK-2,BK2,BKR2,BRB2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 624
MIM: 113503
HGNC: 1030
Ensembl: ENSG00000168398
Variants:
dbSNP: 624
ClinVar: 624
TCGA: ENSG00000168398
COSMIC: BDKRB2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000168398 | ENST00000539359 | P30411 |
| ENSG00000168398 | ENST00000542454 | P30411 |
| ENSG00000168398 | ENST00000554311 | P30411 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712308 | Ace Inhibitors, Plain | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 10904024, 11699055, 12522467, 19744011, 21052031, 21832968, 30672376 | |
| PA443803 | Cough | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 10904024, 11699055, 12522467, 19744011, 21052031, 21832968, 30672376 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 21052031 | |
| PA447288 | Essential hypertension | Disease | ClinicalAnnotation | associated | PD | 12522467 | |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PK | ||
| PA449456 | enalapril | Chemical | ClinicalAnnotation | associated | PD | 12522467, 22706620 | |
| PA450242 | lisinopril | Chemical | ClinicalAnnotation | associated | PD | 12522467 | |
| PA452640 | imidapril | Chemical | ClinicalAnnotation | associated | PD | 12522467 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37703419 | 2024 | Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons. | 4 |
| 37703419 | 2024 | Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons. | 4 |
| 36075965 | 2023 | Function and structure of bradykinin receptor 2 for drug discovery. | 6 |
| 36075965 | 2023 | Function and structure of bradykinin receptor 2 for drug discovery. | 6 |
| 35038454 | 2022 | ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors. | 8 |
| 35132089 | 2022 | Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes. | 7 |
| 36142237 | 2022 | The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency. | 1 |
| 35038454 | 2022 | ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors. | 8 |
| 35132089 | 2022 | Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes. | 7 |
| 36142237 | 2022 | The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency. | 1 |
| 33412234 | 2021 | Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children. | 1 |
| 33497625 | 2021 | Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene. | 7 |
| 33686021 | 2021 | BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma. | 4 |
| 34384552 | 2021 | Association of Variants Near the Bradykinin Receptor B(2) Gene With Angioedema in Patients Taking ACE Inhibitors. | 0 |
| 33412234 | 2021 | Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children. | 1 |
Citation
Dessen P
BDKRB2 (bradykinin receptor B2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45798/bdkrb2
