Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 627
MIM: 113505
HGNC: 1033
Ensembl: ENSG00000176697
Variants:
dbSNP: 627
ClinVar: 627
TCGA: ENSG00000176697
COSMIC: BDNF
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10074 | escitalopram | Chemical | ClinicalAnnotation | associated | PD | 19641488 | |
| PA128406954 | Weight gain | Disease | MultilinkAnnotation | associated | 24279860 | ||
| PA164712362 | Analgesics | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA164712462 | Antiinflammatory agents, non-steroids | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA164712741 | Ergot alkaloids | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA164713257 | Selective serotonin reuptake inhibitors | Chemical | Literature, MultilinkAnnotation | associated | 24930681 | ||
| PA166119022 | methamphetamine dependence | Disease | ClinicalAnnotation | associated | PD | ||
| PA444460 | Heroin Dependence | Disease | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 23651024, 24279859 | |
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 23651024 | |
| PA446876 | Substance-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 24279859, 26401760, 28692418 | |
| PA447207 | Depressive Disorder | Disease | ClinicalAnnotation | associated | PD | 19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 16633140, 24595507, 25560300 | |
| PA447278 | Depression | Disease | ClinicalAnnotation | associated | PD | ||
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 19236730, 19641488, 20016225, 21338649, 22965830, 23619509, 29748862 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862 | |
| PA449233 | desipramine | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449673 | fluoxetine | Chemical | ClinicalAnnotation | associated | PD | 20016225 | |
| PA450243 | lithium | Chemical | Literature, MultilinkAnnotation | associated | 24885933 | ||
| PA450401 | methadone | Chemical | ClinicalAnnotation | associated | PD | 23651024 | |
| PA450403 | methamphetamine | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 24279859, 26401760, 28692418 | |
| PA450657 | nortriptyline | Chemical | ClinicalAnnotation | associated | PD | 19641488 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | PD | 24595507 | |
| PA450801 | paroxetine | Chemical | ClinicalAnnotation | associated | PD | 19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862 | |
| PA451566 | sumatriptan | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 19236730, 20016225, 21338649, 22965830, 23619509, 23733030, 29748862 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD | 16633140, 25560300 | |
| PA452618 | opioids | Chemical | ClinicalAnnotation | associated | 25096645 | ||
| PA452619 | heroin | Chemical | ClinicalAnnotation | associated | PD | 24279859, 26401760, 28692418 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36223549 | 2024 | A pilot study examining BDNF Val66Met polymorphism and biological sex: Relationships with baseline cognitive functioning in adolescent athletes. | 0 |
| 36855816 | 2024 | Sex-dimorphic pathways in the associations between maternal trait anxiety, infant BDNF methylation, and negative emotionality. | 1 |
| 37186275 | 2024 | Effects of a physical exercise or motor activity protocol on cognitive function, lipid profile, and BDNF levels in older adults with mild cognitive impairment. | 3 |
| 37491857 | 2024 | Interaction of Brain-derived Neurotrophic Factor, Exercise, and Fear Extinction: Implications for Post-traumatic Stress Disorder. | 1 |
| 37675625 | 2024 | Human iPSC-derived endothelial cells promote CNS remyelination via BDNF and mTORC1 pathway. | 0 |
| 37706246 | 2024 | Evaluation of the relationship between serum BDNF concentration and indicators of oxidative stress and inflammation in COVID-19 patients with neurological disorders - a pilot study. | 1 |
| 37820958 | 2024 | Influence of BDNF Val66Met genetic polymorphism in Major Depressive Disorder and Body Mass Index: Evidence from a meta-analysis of 6481 individuals. | 1 |
| 37871642 | 2024 | Impact of Strength Training Intensity on Brain-derived Neurotrophic Factor. | 0 |
| 38006577 | 2024 | The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy. | 3 |
| 38008209 | 2024 | TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury. | 1 |
| 38009531 | 2024 | Brain-derived neurotrophic factor (BDNF) downregulates mRNA levels of suppressor of cancer cell invasion (SCAI) variants in cortical neurons. | 0 |
| 38070471 | 2024 | Estrogen, progesterone, cortisol, brain-derived neurotrophic factor, and vascular endothelial growth factor during the luteal phase of the menstrual cycle in women with premenstrual dysphoric disorder. | 0 |
| 38142902 | 2024 | ProBDNF contributed to patrolling monocyte infiltration and renal damage in systemic lupus erythematosus. | 0 |
| 38148427 | 2024 | Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1β and BDNF. | 0 |
| 38164567 | 2024 | Dentate Gyrus Granule Cells Show Stability of BDNF Protein Expression in Mossy Fiber Axons with Age, and Resistance to Alzheimer's Disease Neuropathology in a Mouse Model. | 0 |
Citation
Dessen P
BDNF (brain derived neurotrophic factor)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46287/bdnf
