BEX3 (brain expressed X-linked 3)

2018-02-01  

Identity

HGNC
BEX3
LOCATION
Xq22.2
LOCUSID
27018
ALIAS
Bex,DXS6984E,HGR74,NADE,NGFRAP1

Other Information

Locus ID:

NCBI: 27018
MIM: 300361
HGNC: 13388
Ensembl: ENSG00000166681

Variants:

dbSNP: 27018
ClinVar: 27018
TCGA: ENSG00000166681
COSMIC: BEX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166681ENST00000361298Q00994
ENSG00000166681ENST00000372634Q00994
ENSG00000166681ENST00000372635Q00994
ENSG00000166681ENST00000372645Q00994

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NADE modulates death signallingREACTOMER-HSA-205025

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
118305822002Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.14
127390052003NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo.6
280839952017BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma.4
167770772006Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE.3

Citation

Dessen P

BEX3 (brain expressed X-linked 3)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57308/bex3