Identity
HGNC
LOCATION
3p26.1
LOCUSID
ALIAS
BHLHB2,Clast5,DEC1,HLHB2,SHARP-2,SHARP2,STRA13,Stra14
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8553
MIM: 604256
HGNC: 1046
Ensembl: ENSG00000134107
Variants:
dbSNP: 8553
ClinVar: 8553
TCGA: ENSG00000134107
COSMIC: BHLHE40
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000134107 | ENST00000256495 | O14503 |
| ENSG00000134107 | ENST00000256495 | Q6IB83 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Circadian rhythm | KEGG | ko04710 |
| Circadian rhythm | KEGG | hsa04710 |
| Circadian Clock | REACTOME | R-HSA-400253 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | REACTOME | R-HSA-1368108 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38052232 | 2024 | LncRNA H19 Influences Cellular Activities via the miR-454-3p/BHLHE40 Axis in Anaplastic Thyroid Carcinoma. | 0 |
| 38301894 | 2024 | The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer. | 0 |
| 38671456 | 2024 | DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis. | 0 |
| 38052232 | 2024 | LncRNA H19 Influences Cellular Activities via the miR-454-3p/BHLHE40 Axis in Anaplastic Thyroid Carcinoma. | 0 |
| 38301894 | 2024 | The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer. | 0 |
| 38671456 | 2024 | DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis. | 0 |
| 35688610 | 2023 | Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment. | 60 |
| 36194366 | 2023 | Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10. | 4 |
| 36575343 | 2023 | HIF-1α contributes to metastasis in choriocarcinoma by regulating DEC1 expression. | 0 |
| 36739947 | 2023 | Differentiated embryonic chondrocyte expressed gene-1 is a central signaling component in the development of collagen-induced rheumatoid arthritis. | 1 |
| 36931039 | 2023 | Overcoming ABCB1-mediated multidrug resistance by transcription factor BHLHE40. | 6 |
| 36990072 | 2023 | High serum Bhlhe40 levels are associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus: A cross-sectional study. | 1 |
| 37026212 | 2023 | High expression of BHLHE40 promotes immune infiltration and tumor progression in thyroid cancer. | 0 |
| 37773521 | 2023 | BHLHE40, a potential immune therapy target, regulated by FGD5-AS1/miR-15a-5p in pancreatic cancer. | 1 |
| 35688610 | 2023 | Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment. | 60 |
Citation
Dessen P
BHLHE40 (basic helix-loop-helix family member e40)
Atlas Genet Cytogenet Oncol Haematol. 2009-01-01
Online version: http://atlasgeneticsoncology.org/gene/50621/bhlhe40
