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BMP10 (bone morphogenetic protein 10)

Identity

Other names-
HGNC (Hugo) BMP10
LocusID (NCBI) 27302
Location 2p13.3
Location_base_pair Starts at 69092613 and ends at 69098649 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)BMP10   20869
Cards
Entrez_Gene (NCBI)BMP10  27302  bone morphogenetic protein 10
GeneCards (Weizmann)BMP10
Ensembl (Hinxton)ENSG00000163217 [Gene_View]  chr2:69092613-69098649 [Contig_View]  BMP10 [Vega]
ICGC DataPortalENSG00000163217
cBioPortalBMP10
AceView (NCBI)BMP10
Genatlas (Paris)BMP10
WikiGenes27302
SOURCE (Princeton)NM_014482
Genomic and cartography
GoldenPath (UCSC)BMP10  -  2p13.3   chr2:69092613-69098649 -  2p13.3   [Description]    (hg19-Feb_2009)
EnsemblBMP10 - 2p13.3 [CytoView]
Mapping of homologs : NCBIBMP10 [Mapview]
OMIM608748   
Gene and transcription
Genbank (Entrez)AF101441 BC069080 BC101734 BC105063
RefSeq transcript (Entrez)NM_014482
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_032117 NT_022184 NW_001838769 NW_004929300
Consensus coding sequences : CCDS (NCBI)BMP10
Cluster EST : UnigeneHs.158317 [ NCBI ]
CGAP (NCI)Hs.158317
Alternative Splicing : Fast-db (Paris)GSHG0017694
Alternative Splicing GalleryENSG00000163217
Gene ExpressionBMP10 [ NCBI-GEO ]     BMP10 [ SEEK ]   BMP10 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95393 (Uniprot)
NextProtO95393  [Medical]
With graphics : InterProO95393
Splice isoforms : SwissVarO95393 (Swissvar)
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine [organisation]   Inhibin_asu [organisation]   TGF-b_C [organisation]   TGF-b_N [organisation]   TGF-beta-rel [organisation]   TGFb_CS [organisation]  
Related proteins : CluSTrO95393
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
DMDM Disease mutations27302
Blocks (Seattle)O95393
Human Protein AtlasENSG00000163217 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO95393
HPRD09788
IPIIPI00030115   
Protein Interaction databases
DIP (DOE-UCLA)O95393
IntAct (EBI)O95393
FunCoupENSG00000163217
BioGRIDBMP10
InParanoidO95393
Interologous Interaction database O95393
IntegromeDBBMP10
STRING (EMBL)BMP10
Ontologies - Pathways
Ontology : AmiGOcytokine activity  hormone activity  protein binding  extracellular region  extracellular space  cytoplasm  cell adhesion  adult heart development  growth factor activity  cell surface  negative regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  negative regulation of cardiac muscle hypertrophy  positive regulation of pathway-restricted SMAD protein phosphorylation  cardiac muscle hypertrophy in response to stress  Z disc  extracellular matrix organization  negative regulation of cell growth  negative regulation of cell migration  BMP signaling pathway  activin receptor signaling pathway  receptor serine/threonine kinase binding  sarcomere organization  positive regulation of transcription, DNA-templated  atrial cardiac muscle tissue morphogenesis  ventricular cardiac muscle tissue morphogenesis  ventricular cardiac muscle cell development  regulation of cardiac muscle contraction  cardiac muscle cell proliferation  positive regulation of cardiac muscle cell proliferation  positive regulation of sarcomere organization  heart trabecula formation  pathway-restricted SMAD protein phosphorylation  positive regulation of cell proliferation involved in heart morphogenesis  
Ontology : EGO-EBIcytokine activity  hormone activity  protein binding  extracellular region  extracellular space  cytoplasm  cell adhesion  adult heart development  growth factor activity  cell surface  negative regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  negative regulation of cardiac muscle hypertrophy  positive regulation of pathway-restricted SMAD protein phosphorylation  cardiac muscle hypertrophy in response to stress  Z disc  extracellular matrix organization  negative regulation of cell growth  negative regulation of cell migration  BMP signaling pathway  activin receptor signaling pathway  receptor serine/threonine kinase binding  sarcomere organization  positive regulation of transcription, DNA-templated  atrial cardiac muscle tissue morphogenesis  ventricular cardiac muscle tissue morphogenesis  ventricular cardiac muscle cell development  regulation of cardiac muscle contraction  cardiac muscle cell proliferation  positive regulation of cardiac muscle cell proliferation  positive regulation of sarcomere organization  heart trabecula formation  pathway-restricted SMAD protein phosphorylation  positive regulation of cell proliferation involved in heart morphogenesis  
Pathways : BIOCARTAALK in cardiac myocytes [Genes]   
Protein Interaction DatabaseBMP10
Wikipedia pathwaysBMP10
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)BMP10
snp3D : Map Gene to Disease27302
SNP (GeneSNP Utah)BMP10
SNP : HGBaseBMP10
Genetic variants : HAPMAPBMP10
Exome VariantBMP10
1000_GenomesBMP10 
ICGC programENSG00000163217 
Somatic Mutations in Cancer : COSMICBMP10 
CONAN: Copy Number AnalysisBMP10 
Mutations and Diseases : HGMDBMP10
Genomic VariantsBMP10  BMP10 [DGVbeta]
dbVarBMP10
ClinVarBMP10
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM608748   
MedgenBMP10
GENETestsBMP10
Disease Genetic AssociationBMP10
Huge Navigator BMP10 [HugePedia]  BMP10 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneBMP10
Homology/Alignments : Family Browser (UCSC)BMP10
Phylogenetic Trees/Animal Genes : TreeFamBMP10
Chemical/Protein Interactions : CTD27302
Chemical/Pharm GKB GenePA134953092
Clinical trialBMP10
Cancer Resource (Charite)ENSG00000163217
Other databases
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
CoreMineBMP10
iHOPBMP10
OncoSearchBMP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:25:19 CEST 2014

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