BMP6 (bone morphogenetic protein 6)

2003-11-01  

Identity

HGNC
LOCATION
6p24.3
LOCUSID
ALIAS
VGR,VGR1
FUSION GENES

Other Information

Locus ID:

NCBI: 654
MIM: 112266
HGNC: 1073
Ensembl: ENSG00000153162

Variants:

dbSNP: 654
ClinVar: 654
TCGA: ENSG00000153162
COSMIC: BMP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153162ENST00000283147P22004

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
BMP signalingKEGGhsa_M00679
BMP signalingKEGGM00679

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192524882009Lack of the bone morphogenetic protein BMP6 induces massive iron overload.220
190752232008Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.135
172381352007Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6.97
183268172008Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.86
184365332008BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.86
208441212010Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
186326322008Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms.49
192660772009Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.48
145580862003Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis.45

Citation

Dessen P

BMP6 (bone morphogenetic protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/813/bmp6