Atlas of Genetics and Cytogenetics in Oncology and Haematology

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BNIP2 (BCL2 interacting protein 2)

Identity

Alias_namesBCL2/adenovirus E1B 19kDa interacting protein 2
Alias_symbol (synonym)Nip2
BNIP-2
Other aliasNIP2
HGNC (Hugo) BNIP2
LocusID (NCBI) 663
Atlas_Id 821
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 59659146 and ends at 59689534 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MYO1E (15q22.2) / BNIP2 (15q22.2)MYO1E 15q22.2 / BNIP2 15q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  MYO1E/BNIP2 (15q22)

External links

Nomenclature
HGNC (Hugo)BNIP2   1083
Cards
Entrez_Gene (NCBI)BNIP2  663  BCL2 interacting protein 2
AliasesBNIP-2; NIP2
GeneCards (Weizmann)BNIP2
Ensembl hg19 (Hinxton)ENSG00000140299 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140299 [Gene_View]  ENSG00000140299 [Sequence]  chr15:59659146-59689534 [Contig_View]  BNIP2 [Vega]
ICGC DataPortalENSG00000140299
TCGA cBioPortalBNIP2
AceView (NCBI)BNIP2
Genatlas (Paris)BNIP2
WikiGenes663
SOURCE (Princeton)BNIP2
Genetics Home Reference (NIH)BNIP2
Genomic and cartography
GoldenPath hg38 (UCSC)BNIP2  -     chr15:59659146-59689534 -  15q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BNIP2  -     15q22.2   [Description]    (hg19-Feb_2009)
GoldenPathBNIP2 - 15q22.2 [CytoView hg19]  BNIP2 - 15q22.2 [CytoView hg38]
ImmunoBaseENSG00000140299
Mapping of homologs : NCBIBNIP2 [Mapview hg19]  BNIP2 [Mapview hg38]
OMIM603292   
Gene and transcription
Genbank (Entrez)AI914901 AK125533 AK299628 AK308237 BC002461
RefSeq transcript (Entrez)NM_001320674 NM_001320675 NM_001368057 NM_001368058 NM_001368059 NM_001368060 NM_001368061 NM_004330
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BNIP2
Cluster EST : UnigeneHs.646490 [ NCBI ]
CGAP (NCI)Hs.646490
Alternative Splicing GalleryENSG00000140299
Gene ExpressionBNIP2 [ NCBI-GEO ]   BNIP2 [ EBI - ARRAY_EXPRESS ]   BNIP2 [ SEEK ]   BNIP2 [ MEM ]
Gene Expression Viewer (FireBrowse)BNIP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)663
GTEX Portal (Tissue expression)BNIP2
Human Protein AtlasENSG00000140299-BNIP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12982   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12982  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12982
Splice isoforms : SwissVarQ12982
PhosPhoSitePlusQ12982
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)   
Domains : Interpro (EBI)Bcl2-/adenovirus-E1B    CRAL-TRIO_dom    CRAL-TRIO_dom_sf   
Domain families : Pfam (Sanger)BNIP2 (PF12496)    CRAL_TRIO_2 (PF13716)   
Domain families : Pfam (NCBI)pfam12496    pfam13716   
Domain families : Smart (EMBL)SEC14 (SM00516)  
Conserved Domain (NCBI)BNIP2
DMDM Disease mutations663
Blocks (Seattle)BNIP2
SuperfamilyQ12982
Human Protein Atlas [tissue]ENSG00000140299-BNIP2 [tissue]
Peptide AtlasQ12982
HPRD04481
IPIIPI00943060   IPI00030399   IPI00916941   IPI00917112   IPI00916658   
Protein Interaction databases
DIP (DOE-UCLA)Q12982
IntAct (EBI)Q12982
FunCoupENSG00000140299
BioGRIDBNIP2
STRING (EMBL)BNIP2
ZODIACBNIP2
Ontologies - Pathways
QuickGOQ12982
Ontology : AmiGOexopolyphosphatase activity  GTPase activator activity  calcium ion binding  protein binding  nuclear envelope  cytoplasm  cytoplasm  cytosol  polyphosphate catabolic process  apoptotic process  apoptotic process  negative regulation of apoptotic process  intracellular membrane-bounded organelle  positive regulation of GTPase activity  perinuclear region of cytoplasm  positive regulation of muscle cell differentiation  
Ontology : EGO-EBIexopolyphosphatase activity  GTPase activator activity  calcium ion binding  protein binding  nuclear envelope  cytoplasm  cytoplasm  cytosol  polyphosphate catabolic process  apoptotic process  apoptotic process  negative regulation of apoptotic process  intracellular membrane-bounded organelle  positive regulation of GTPase activity  perinuclear region of cytoplasm  positive regulation of muscle cell differentiation  
NDEx NetworkBNIP2
Atlas of Cancer Signalling NetworkBNIP2
Wikipedia pathwaysBNIP2
Orthology - Evolution
OrthoDB663
GeneTree (enSembl)ENSG00000140299
Phylogenetic Trees/Animal Genes : TreeFamBNIP2
HOGENOMQ12982
Homologs : HomoloGeneBNIP2
Homology/Alignments : Family Browser (UCSC)BNIP2
Gene fusions - Rearrangements
Fusion : MitelmanMYO1E/BNIP2 [15q22.2/15q22.2]  [t(15;15)(q22;q22)]  
Fusion PortalMYO1E 15q22.2 BNIP2 15q22.2 BRCA LUAD
Fusion : QuiverBNIP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBNIP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BNIP2
dbVarBNIP2
ClinVarBNIP2
1000_GenomesBNIP2 
Exome Variant ServerBNIP2
ExAC (Exome Aggregation Consortium)ENSG00000140299
GNOMAD BrowserENSG00000140299
Varsome BrowserBNIP2
Genetic variants : HAPMAP663
Genomic Variants (DGV)BNIP2 [DGVbeta]
DECIPHERBNIP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBNIP2 
Mutations
ICGC Data PortalBNIP2 
TCGA Data PortalBNIP2 
Broad Tumor PortalBNIP2
OASIS PortalBNIP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBNIP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DBNIP2
Mutations and Diseases : HGMDBNIP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BNIP2
DgiDB (Drug Gene Interaction Database)BNIP2
DoCM (Curated mutations)BNIP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BNIP2 (select a term)
intoGenBNIP2
Cancer3DBNIP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603292   
Orphanet
DisGeNETBNIP2
MedgenBNIP2
Genetic Testing Registry BNIP2
NextProtQ12982 [Medical]
TSGene663
GENETestsBNIP2
Target ValidationBNIP2
Huge Navigator BNIP2 [HugePedia]
snp3D : Map Gene to Disease663
BioCentury BCIQBNIP2
ClinGenBNIP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD663
Chemical/Pharm GKB GenePA25393
Clinical trialBNIP2
Miscellaneous
canSAR (ICR)BNIP2 (select the gene name)
DataMed IndexBNIP2
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBNIP2
EVEXBNIP2
GoPubMedBNIP2
iHOPBNIP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:34:22 CET 2019
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