BORA (BORA aurora kinase A activator)

2016-01-01  

Identity

HGNC
LOCATION
13q21.33
LOCUSID
ALIAS
C13orf34
FUSION GENES

Other Information

Locus ID:

NCBI: 79866
MIM: 610510
HGNC: 24724
Ensembl: ENSG00000136122

Variants:

dbSNP: 79866
ClinVar: 79866
TCGA: ENSG00000136122
COSMIC: BORA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136122ENST00000377814H3BLY2
ENSG00000136122ENST00000390667Q6PGQ7
ENSG00000136122ENST00000613797A0A087WV86
ENSG00000136122ENST00000618209A0A087WVC9
ENSG00000136122ENST00000651376A0A494C1R8
ENSG00000136122ENST00000651477Q6PGQ7
ENSG00000136122ENST00000652266Q6PGQ7

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185662902008Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.239
209238222010Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.79
183787702008Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression.65
185216202008Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.61
243383642014Bora and Aurora-A continue to activate Plk1 in mitosis.41
194872762009Aurora-A and hBora join the game of Polo.19
239704192013Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex.16
270684772016Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.16
235927822013Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein.14
278318272016Mitotic entry: The interplay between Cdk1, Plk1 and Bora.11

Citation

Dessen P

BORA (BORA aurora kinase A activator)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55602/bora