BPHL (biphenyl hydrolase like)

2014-11-01  

Identity

HGNC
BPHL
LOCATION
6p25.2
LOCUSID
670
ALIAS
BPH-RP,MCNAA,VACVASE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 670
MIM: 603156
HGNC: 1094
Ensembl: ENSG00000137274

Variants:

dbSNP: 670
ClinVar: 670
TCGA: ENSG00000137274
COSMIC: BPHL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137274ENST00000380368Q49AI2
ENSG00000137274ENST00000380375Q86WA6
ENSG00000137274ENST00000380375A0A024QZY0
ENSG00000137274ENST00000380379Q86WA6
ENSG00000137274ENST00000423798H7C0M3
ENSG00000137274ENST00000424847F2Z2Q1
ENSG00000137274ENST00000430655F2Z2Q1
ENSG00000137274ENST00000433912B4DML3
ENSG00000137274ENST00000434640Q86WA6
ENSG00000137274ENST00000434640A0A024QZY0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127326462003Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
158325082004A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.14
253332742014Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase.9

Citation

Dessen P

BPHL (biphenyl hydrolase like)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60791/bphl