BRCA2 (breast cancer 2, early onset)

Identity

Other names	BRCC2
	FACD
	FAD
	FAD1
	FANCB
	FANCD
	FANCD1
HGNC	BRCA2
Location	13q12-q13
Location_base_pair	Starts at 31787617 and ends at 31871809 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	BRCA2   1101
Entrez_Gene	BRCA2  675  breast cancer 2, early onset
	Cards
GeneCards	BRCA2
Ensembl	BRCA2 [Search_View]   ENSG00000139618 [Gene_View]
Genatlas	BRCA2
GeneLynx	BRCA2
eGenome	BRCA2
euGene	675
	Genomic and cartography
GoldenPath	BRCA2  -     chr13:31787617-31871809 +  13q13.1   [Description]    (hg18-March_2006)
Ensembl	BRCA2 - 13q13.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BRCA2
	Gene and transcription
Genbank	BC026160 [ ENTREZ ]
Genbank	BC047568 [ ENTREZ ]
Genbank	DQ897648 [ ENTREZ ]
Genbank	U43746 [ ENTREZ ]
RefSeq	NM_000059 [ SRS ]    NM_000059 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	AC_000145 [ SRS ]    AC_000145 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NT_024524 [ SRS ]    NT_024524 [ ENTREZ ]
RefSeq	NW_001838072 [ SRS ]    NW_001838072 [ ENTREZ ]
RefSeq	NW_925473 [ SRS ]    NW_925473 [ ENTREZ ]
AceView	BRCA2 AceView - NCBI
Unigene	Hs.34012 [ SRS ]    Hs.34012 [ NCBI ]     HS34012 [ spliceNest ]
Fast-db	2649 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P51587 [ SRS]    P51587 [ EXPASY ]     P51587 [ INTERPRO ]     P51587 [ UNIPROT ]
Prosite	PS50138 BRCA2_REPEAT [ SRS ]    PS50138 BRCA2_REPEAT [ Expasy ]
Interpro	IPR015187 BRCA-2_OB_1 [ SRS ]    IPR015187 BRCA-2_OB_1 [ EBI ]
Interpro	IPR015188 BRCA-2_OB_3 [ SRS ]    IPR015188 BRCA-2_OB_3 [ EBI ]
Interpro	IPR011370 BRCA2 [ SRS ]    IPR011370 BRCA2 [ EBI ]
Interpro	IPR015252 BRCA2_helical [ SRS ]    IPR015252 BRCA2_helical [ EBI ]
Interpro	IPR002093 BRCA2_repeat [ SRS ]    IPR002093 BRCA2_repeat [ EBI ]
Interpro	IPR015525 BRCA_2 [ SRS ]    IPR015525 BRCA_2 [ EBI ]
Interpro	IPR015205 Tower [ SRS ]    IPR015205 Tower [ EBI ]
CluSTr	P51587
Pfam	PF09169 BRCA-2_helical [ SRS ]    PF09169 BRCA-2_helical [ Sanger ]    pfam09169 [ NCBI-CDD ]
Pfam	PF09103 BRCA-2_OB1 [ SRS ]    PF09103 BRCA-2_OB1 [ Sanger ]    pfam09103 [ NCBI-CDD ]
Pfam	PF09104 BRCA-2_OB3 [ SRS ]    PF09104 BRCA-2_OB3 [ Sanger ]    pfam09104 [ NCBI-CDD ]
Pfam	PF00634 BRCA2 [ SRS ]    PF00634 BRCA2 [ Sanger ]    pfam00634 [ NCBI-CDD ]
Pfam	PF09121 Tower [ SRS ]    PF09121 Tower [ Sanger ]    pfam09121 [ NCBI-CDD ]
Blocks	P51587
PDB	1N0W [ SRS ]    1N0W [ PdbSum ],   1N0W [ IMB ]   1N0W [ RSDB ]
HPRD	02554
	Protein Interaction databases
DIP	P51587
IntAct	P51587
	Polymorphism : SNP, mutations, diseases
OMIM	114480;155255;176807;194070;260350;600185;605724    [ map ]
GENECLINICS	114480;155255;176807;194070;260350;600185;605724
SNP	BRCA2 [dbSNP-NCBI]
SNP	NM_000059 [SNP-NCI]
SNP	BRCA2 [GeneSNPs - Utah]  BRCA2] [HGBASE - SRS]
HAPMAP	BRCA2 [HAPMAP]
COSMIC	BRCA2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	BRCA2
	General knowledge
Family Browser	BRCA2 [UCSC Family Browser]
SOURCE	NM_000059
SMD	Hs.34012
SAGE	Hs.34012
GO	double-strand break repair via homologous recombination [Amigo]  double-strand break repair via homologous recombination
GO	oocyte maturation [Amigo]  oocyte maturation
GO	inner cell mass cell proliferation [Amigo]  inner cell mass cell proliferation
GO	single-stranded DNA binding [Amigo]  single-stranded DNA binding
GO	histone acetyltransferase activity [Amigo]  histone acetyltransferase activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	nucleoplasm [Amigo]  nucleoplasm
GO	cytoplasm [Amigo]  cytoplasm
GO	centrosome [Amigo]  centrosome
GO	nucleotide-excision repair [Amigo]  nucleotide-excision repair
GO	DNA recombination [Amigo]  DNA recombination
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [Amigo]  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO	regulation of S phase of mitotic cell cycle [Amigo]  regulation of S phase of mitotic cell cycle
GO	male meiosis I [Amigo]  male meiosis I
GO	spermatogenesis [Amigo]  spermatogenesis
GO	brain development [Amigo]  brain development
GO	cell aging [Amigo]  cell aging
GO	response to nutrient [Amigo]  response to nutrient
GO	female gonad development [Amigo]  female gonad development
GO	response to X-ray [Amigo]  response to X-ray
GO	response to UV-C [Amigo]  response to UV-C
GO	response to gamma radiation [Amigo]  response to gamma radiation
GO	transcription activator activity [Amigo]  transcription activator activity
GO	secretory granule [Amigo]  secretory granule
GO	mammary gland development [Amigo]  mammary gland development
GO	cytokinesis during cell cycle [Amigo]  cytokinesis during cell cycle
GO	BRCA2-MAGE-D1 complex [Amigo]  BRCA2-MAGE-D1 complex
GO	response to genistein [Amigo]  response to genistein
GO	negative regulation of mammary gland epithelial cell proliferation [Amigo]  negative regulation of mammary gland epithelial cell proliferation
GO	multicellular organism growth [Amigo]  multicellular organism growth
GO	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [Amigo]  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO	chordate embryonic development [Amigo]  chordate embryonic development
GO	gamma-tubulin binding [Amigo]  gamma-tubulin binding
GO	response to estrogen stimulus [Amigo]  response to estrogen stimulus
GO	positive regulation of mitotic cell cycle [Amigo]  positive regulation of mitotic cell cycle
GO	replication fork protection [Amigo]  replication fork protection
GO	centrosome duplication [Amigo]  centrosome duplication
BIOCARTA	Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility    [Genes]
PubGene	BRCA2
TreeFam	BRCA2
CTD	675 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BRCA2 Related clones (RZPD - Berlin)
	PubMed
PubMed	499 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:32:32 2008