BRDT (bromodomain testis associated)

2006-10-01  

Identity

HGNC
BRDT
LOCATION
1p22.1
LOCUSID
676
ALIAS
BRD6,CT9,SPGF21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 676
MIM: 602144
HGNC: 1105
Ensembl: ENSG00000137948

Variants:

dbSNP: 676
ClinVar: 676
TCGA: ENSG00000137948
COSMIC: BRDT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137948ENST00000355011C9J0Z0
ENSG00000137948ENST00000362005Q58F21
ENSG00000137948ENST00000370389Q58F21
ENSG00000137948ENST00000394530Q58F21
ENSG00000137948ENST00000399546Q58F21
ENSG00000137948ENST00000402388Q58F21
ENSG00000137948ENST00000423434C9JD82
ENSG00000137948ENST00000426141C9JJU3
ENSG00000137948ENST00000427104C9J1F7
ENSG00000137948ENST00000440509C9JDL5
ENSG00000137948ENST00000448194C9J1F7
ENSG00000137948ENST00000449584C9JMP1
ENSG00000137948ENST00000450792C9JLZ2
ENSG00000137948ENST00000457265C9JQ27
ENSG00000137948ENST00000548992F8VZ63
ENSG00000137948ENST00000552654F8W0H2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
281999652017Whole-exome sequencing identified a homozygous BRDT mutation in a patient with acephalic spermatozoa.12
302010022018FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma.10
205387142010The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men.9
220357302012Expression of BET genes in testis of men with different spermatogenic impairments.5
156478492005Molecular cloning and expression of a novel alternative splice variant of BRDT gene.3
248657962014BRDT gene sequence in human testicular pathologies and the implication of its single nucleotide polymorphism (rs3088232) on fertility.3
253743272015Genetic association study of RNF8 and BRDT variants with non-obstructive azoospermia in the Chinese Han population.3
289453512017Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.3

Citation

Dessen P

BRDT (bromodomain testis associated)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43172/brdt