BRS3 (bombesin receptor subtype 3)

2007-02-01  

Identity

HGNC
LOCATION
Xq26.3
LOCUSID
ALIAS
BB3,BB3R,BBR3
FUSION GENES

Other Information

Locus ID:

NCBI: 680
MIM: 300107
HGNC: 1113
Ensembl: ENSG00000102239

Variants:

dbSNP: 680
ClinVar: 680
TCGA: ENSG00000102239
COSMIC: BRS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102239ENST00000370648P32247

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
260209402015The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.32
121026382002Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).20
218785132011Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.19
252410332014Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
169797892006Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells.6
242205022014Human BRS-3 receptor: functions/role in cell signaling pathways and glucose metabolism in obese or diabetic myocytes.6
294103202018A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3.5
173552232007PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.4

Citation

Dessen P

BRS3 (bombesin receptor subtype 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45724/brs3