C1QBP (complement C1q binding protein)

2008-10-01  

Identity

HGNC
C1QBP
LOCATION
17p13.2
LOCUSID
708
ALIAS
COXPD33,GC1QBP,HABP1,SF2AP32,SF2p32,gC1Q-R,gC1qR,p32
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 708
MIM: 601269
HGNC: 1243
Ensembl: ENSG00000108561

Variants:

dbSNP: 708
ClinVar: 708
TCGA: ENSG00000108561
COSMIC: C1QBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108561ENST00000225698Q07021
ENSG00000108561ENST00000570805I3L3Q7
ENSG00000108561ENST00000574444I3L3B0
ENSG00000108561ENST00000576122A0A0G2JLC0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201008662010Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation.102
187574372008Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma.97
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
185387372008Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.57
191645502009Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria.50
151637342004Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt.39
178815112007HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL-12 production.38
179078012007Plasmodium falciparum uses gC1qR/HABP1/p32 as a receptor to bind to vascular endothelium and for platelet-mediated clumping.30
161771182005gC1q receptor ligation selectively down-regulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway.29
195656302009Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer.26

Citation

Dessen P

C1QBP (complement C1q binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50394/c1qbp