Atlas of Genetics and Cytogenetics in Oncology and Haematology

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C2CD2L (C2CD2 like)

Identity

Alias_namesTMEM24
transmembrane protein 24
Alias_symbol (synonym)KIAA0285
Other aliasDLNB23
HGNC (Hugo) C2CD2L
LocusID (NCBI) 9854
Atlas_Id 54169
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 119107344 and ends at 119118544 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD2L (11q23.3) / DDX10 (11q22.3)PTPRJ (11p11.2) / C2CD2L (11q23.3)ZNF585B (19q13.12) / C2CD2L (11q23.3)
C2CD2L 11q23.3 / DDX10 11q22.3PTPRJ 11p11.2 / C2CD2L 11q23.3ZNF585B 19q13.12 / C2CD2L 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(11;11)(p11;q23) PTPRJ/C2CD2L
t(11;11)(q22;q23) C2CD2L/DDX10
t(11;19)(q23;q13) ZNF585B/C2CD2L

External links

Nomenclature
HGNC (Hugo)C2CD2L   29000
Cards
Entrez_Gene (NCBI)C2CD2L  9854  C2CD2 like
AliasesDLNB23; TMEM24
GeneCards (Weizmann)C2CD2L
Ensembl hg19 (Hinxton)ENSG00000172375 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172375 [Gene_View]  ENSG00000172375 [Sequence]  chr11:119107344-119118544 [Contig_View]  C2CD2L [Vega]
ICGC DataPortalENSG00000172375
TCGA cBioPortalC2CD2L
AceView (NCBI)C2CD2L
Genatlas (Paris)C2CD2L
WikiGenes9854
SOURCE (Princeton)C2CD2L
Genetics Home Reference (NIH)C2CD2L
Genomic and cartography
GoldenPath hg38 (UCSC)C2CD2L  -     chr11:119107344-119118544 +  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)C2CD2L  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathC2CD2L - 11q23.3 [CytoView hg19]  C2CD2L - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000172375
Mapping of homologs : NCBIC2CD2L [Mapview hg19]  C2CD2L [Mapview hg38]
OMIM617582   
Gene and transcription
Genbank (Entrez)AB006623 AB094094 AK025223 BC003598 BC010071
RefSeq transcript (Entrez)NM_001290474 NM_001382611 NM_001382612 NM_001382613 NM_014807
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)C2CD2L
Alternative Splicing GalleryENSG00000172375
Gene ExpressionC2CD2L [ NCBI-GEO ]   C2CD2L [ EBI - ARRAY_EXPRESS ]   C2CD2L [ SEEK ]   C2CD2L [ MEM ]
Gene Expression Viewer (FireBrowse)C2CD2L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9854
GTEX Portal (Tissue expression)C2CD2L
Human Protein AtlasENSG00000172375-C2CD2L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14523   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14523  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14523
Splice isoforms : SwissVarO14523
PhosPhoSitePlusO14523
Domaine pattern : Prosite (Expaxy)C2 (PS50004)   
Domains : Interpro (EBI)C2CD2/C2CD2L    SMP_C2CD2L   
Domain families : Pfam (Sanger)SMP_C2CD2L (PF18696)   
Domain families : Pfam (NCBI)pfam18696   
Conserved Domain (NCBI)C2CD2L
DMDM Disease mutations9854
Blocks (Seattle)C2CD2L
PDB (RSDB)5TOD   
PDB Europe5TOD   
PDB (PDBSum)5TOD   
PDB (IMB)5TOD   
Structural Biology KnowledgeBase5TOD   
SCOP (Structural Classification of Proteins)5TOD   
CATH (Classification of proteins structures)5TOD   
SuperfamilyO14523
Human Protein Atlas [tissue]ENSG00000172375-C2CD2L [tissue]
Peptide AtlasO14523
HPRD15533
IPIIPI00791103   IPI00394781   
Protein Interaction databases
DIP (DOE-UCLA)O14523
IntAct (EBI)O14523
FunCoupENSG00000172375
BioGRIDC2CD2L
STRING (EMBL)C2CD2L
ZODIACC2CD2L
Ontologies - Pathways
QuickGOO14523
Ontology : AmiGOendoplasmic reticulum membrane  phosphatidylinositol transporter activity  phospholipid transport  integral component of membrane  cortical endoplasmic reticulum  phosphatidylinositol binding  positive regulation of insulin secretion involved in cellular response to glucose stimulus  insulin binding  cytoplasmic side of apical plasma membrane  intermembrane lipid transfer  
Ontology : EGO-EBIendoplasmic reticulum membrane  phosphatidylinositol transporter activity  phospholipid transport  integral component of membrane  cortical endoplasmic reticulum  phosphatidylinositol binding  positive regulation of insulin secretion involved in cellular response to glucose stimulus  insulin binding  cytoplasmic side of apical plasma membrane  intermembrane lipid transfer  
NDEx NetworkC2CD2L
Atlas of Cancer Signalling NetworkC2CD2L
Wikipedia pathwaysC2CD2L
Orthology - Evolution
OrthoDB9854
GeneTree (enSembl)ENSG00000172375
Phylogenetic Trees/Animal Genes : TreeFamC2CD2L
HOGENOMO14523
Homologs : HomoloGeneC2CD2L
Homology/Alignments : Family Browser (UCSC)C2CD2L
Gene fusions - Rearrangements
Fusion : MitelmanC2CD2L/DDX10 [11q23.3/11q22.3]  
Fusion : MitelmanPTPRJ/C2CD2L [11p11.2/11q23.3]  [t(11;11)(p11;q23)]  
Fusion : MitelmanZNF585B/C2CD2L [19q13.12/11q23.3]  [t(11;19)(q23;q13)]  
Fusion PortalC2CD2L 11q23.3 DDX10 11q22.3 LAML
Fusion PortalPTPRJ 11p11.2 C2CD2L 11q23.3 LAML
Fusion PortalZNF585B 19q13.12 C2CD2L 11q23.3 LAML
Fusion : QuiverC2CD2L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerC2CD2L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)C2CD2L
dbVarC2CD2L
ClinVarC2CD2L
1000_GenomesC2CD2L 
Exome Variant ServerC2CD2L
ExAC (Exome Aggregation Consortium)ENSG00000172375
GNOMAD BrowserENSG00000172375
Varsome BrowserC2CD2L
Genetic variants : HAPMAP9854
Genomic Variants (DGV)C2CD2L [DGVbeta]
DECIPHERC2CD2L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisC2CD2L 
Mutations
ICGC Data PortalC2CD2L 
TCGA Data PortalC2CD2L 
Broad Tumor PortalC2CD2L
OASIS PortalC2CD2L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICC2CD2L  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DC2CD2L
Mutations and Diseases : HGMDC2CD2L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch C2CD2L
DgiDB (Drug Gene Interaction Database)C2CD2L
DoCM (Curated mutations)C2CD2L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)C2CD2L (select a term)
intoGenC2CD2L
Cancer3DC2CD2L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617582   
Orphanet
DisGeNETC2CD2L
MedgenC2CD2L
Genetic Testing Registry C2CD2L
NextProtO14523 [Medical]
TSGene9854
GENETestsC2CD2L
Target ValidationC2CD2L
Huge Navigator C2CD2L [HugePedia]
snp3D : Map Gene to Disease9854
BioCentury BCIQC2CD2L
ClinGenC2CD2L
Clinical trials, drugs, therapy
Protein Interactions : CTD9854
Pharm GKB GenePA162379049
Clinical trialC2CD2L
Miscellaneous
canSAR (ICR)C2CD2L (select the gene name)
HarmonizomeC2CD2L
DataMed IndexC2CD2L
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineC2CD2L
EVEXC2CD2L
GoPubMedC2CD2L
iHOPC2CD2L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Jun 30 20:10:54 CEST 2020
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