C3AR1 (complement C3a receptor 1)

2016-05-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
AZ3B,C3AR,HNFAG09
FUSION GENES

Other Information

Locus ID:

NCBI: 719
MIM: 605246
HGNC: 1319
Ensembl: ENSG00000171860

Variants:

dbSNP: 719
ClinVar: 719
TCGA: ENSG00000171860
COSMIC: C3AR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171860ENST00000307637Q16581
ENSG00000171860ENST00000307637A8K2H7
ENSG00000171860ENST00000546241F5GZE6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125114072003Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1.66
204845952010Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells.47
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
243213962014Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation.35
213712352011Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells.34
304159982018Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease.32
150391372004Complement factors c3a, c4a, and c5a in chronic obstructive pulmonary disease and asthma.28
152784362004Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma.26
150670692004A leucine-rich repeat motif of Leishmania parasite surface antigen 2 binds to macrophages through the complement receptor 3.25
215898582011Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells.24

Citation

Dessen P

C3AR1 (complement C3a receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55773/c3ar1