C5AR2 (complement C5a receptor 2)

2013-03-01  

Identity

HGNC
C5AR2
LOCATION
19q13.32
LOCUSID
27202
ALIAS
C5L2,GPF77,GPR77

Other Information

Locus ID:

NCBI: 27202
MIM: 609949
HGNC: 4527
Ensembl: ENSG00000134830

Variants:

dbSNP: 27202
ClinVar: 27202
TCGA: ENSG00000134830
COSMIC: C5AR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134830ENST00000595464Q9P296
ENSG00000134830ENST00000600626Q9P296

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
200444842010The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.85
232398222013C5L2: a controversial receptor of complement anaphylatoxin, C5a.63
117730632002The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).62
117730632002The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).62
158337472005C5L2 is a functional receptor for acylation-stimulating protein.50
191006242009The human complement fragment receptor, C5L2, is a recycling decoy receptor.47
125408462003The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.39
145708962004C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.26
156349362005Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.24
285763242017New concepts on the therapeutic control of complement anaphylatoxin receptors.20

Citation

Dessen P

C5AR2 (complement C5a receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-03-01

Online version: http://atlasgeneticsoncology.org/gene/53215/c5ar2