Identity
HGNC
LOCATION
15q22.2
LOCUSID
ALIAS
CA-XII,CAXII,HsT18816,T18816
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 771
MIM: 603263
HGNC: 1371
Ensembl: ENSG00000074410
Variants:
dbSNP: 771
ClinVar: 771
TCGA: ENSG00000074410
COSMIC: CA12
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000074410 | ENST00000178638 | O43570 |
| ENSG00000074410 | ENST00000344366 | O43570 |
| ENSG00000074410 | ENST00000422263 | B3KUB4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Nitrogen metabolism | KEGG | ko00910 |
| Nitrogen metabolism | KEGG | hsa00910 |
| Metabolism | REACTOME | R-HSA-1430728 |
| Reversible hydration of carbon dioxide | REACTOME | R-HSA-1475029 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA448871 | celecoxib | Chemical | Pathway | associated | 22336956 | ||
| PA451728 | topiramate | Chemical | ClinicalAnnotation | associated | PD | 21278619 | |
| PA451978 | zonisamide | Chemical | ClinicalAnnotation | associated | PD | 21278619 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37587861 | 2023 | Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cells. | 1 |
| 37587861 | 2023 | Trafficking of carbonic anhydrase 12 and bicarbonate transporters by histamine stimulation mediates intracellular acidic scenario in lung cancer cells. | 1 |
| 35362480 | 2022 | Carbonic anhydrase XII mediates the survival and prometastatic functions of macrophages in human hepatocellular carcinoma. | 26 |
| 35362480 | 2022 | Carbonic anhydrase XII mediates the survival and prometastatic functions of macrophages in human hepatocellular carcinoma. | 26 |
| 34696661 | 2021 | Carbonic anhydrase 12 gene silencing reverses the sensitivity of paclitaxel in drug-resistant breast cancer cells. | 6 |
| 34696661 | 2021 | Carbonic anhydrase 12 gene silencing reverses the sensitivity of paclitaxel in drug-resistant breast cancer cells. | 6 |
| 31979064 | 2020 | Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling. | 9 |
| 31979064 | 2020 | Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling. | 9 |
| 30632488 | 2019 | SCNN1B and CA12 play vital roles in occurrence of congenital bilateral absence of vas deferens (CBAVD). | 5 |
| 30784287 | 2019 | High expression of carbonic anhydrase 12 (CA12) is associated with good prognosis in breast cancer. | 16 |
| 31221477 | 2019 | Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells. | 6 |
| 31366496 | 2019 | Humanized Monoclonal Antibody Blocking Carbonic Anhydrase 12 Enzymatic Activity Leads to Reduced Tumor Growth In Vitro. | 8 |
| 30632488 | 2019 | SCNN1B and CA12 play vital roles in occurrence of congenital bilateral absence of vas deferens (CBAVD). | 5 |
| 30784287 | 2019 | High expression of carbonic anhydrase 12 (CA12) is associated with good prognosis in breast cancer. | 16 |
| 31221477 | 2019 | Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells. | 6 |
Citation
Dessen P
CA12 (carbonic anhydrase 12)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/896/ca12
