CA3 (carbonic anhydrase 3)

2014-11-01  

Identity

HGNC
LOCATION
8q21.2
LOCUSID
ALIAS
CAIII,Car3
FUSION GENES

Other Information

Locus ID:

NCBI: 761
MIM: 114750
HGNC: 1374
Ensembl: ENSG00000164879

Variants:

dbSNP: 761
ClinVar: 761
TCGA: ENSG00000164879
COSMIC: CA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164879ENST00000285381P07451
ENSG00000164879ENST00000285381V9HWA3
ENSG00000164879ENST00000520921E5RHI4

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Nitrogen metabolismKEGGko00910
Nitrogen metabolismKEGGhsa00910
MetabolismREACTOMER-HSA-1430728
Reversible hydration of carbon dioxideREACTOMER-HSA-1475029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
227971482012Mass spectrometry-based proteomic analysis of middle-aged vs. aged vastus lateralis reveals increased levels of carbonic anhydrase isoform 3 in senescent human skeletal muscle.24
183225452008A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction.13
230495972012Carbonic anhydrases III and IV autoantibodies in rheumatoid arthritis, systemic lupus erythematosus, diabetes, hypertensive renal disease, and heart failure.11
184442442008Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway.10
295596612018Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death.6
124843422002Proton transfer within the active-site cavity of carbonic anhydrase III.4
193012022009Carbonic anhydrase III is insufficient in muscles of myasthenia gravis patients.3
121719262002Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.2
239817572013Anti-carbonic anhydrase III autoantibodies in vasculitis syndrome.2
119765002002Crystallization and preliminary X-ray analysis of human carbonic anhydrase III.1

Citation

Dessen P

CA3 (carbonic anhydrase 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61341/ca3