CAB39 (calcium binding protein 39)

2007-04-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
CGI-66,MO25
FUSION GENES

Other Information

Locus ID:

NCBI: 51719
MIM: 612174
HGNC: 20292
Ensembl: ENSG00000135932

Variants:

dbSNP: 51719
ClinVar: 51719
TCGA: ENSG00000135932
COSMIC: CAB39

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135932ENST00000258418Q9Y376
ENSG00000135932ENST00000258418A0A024R496
ENSG00000135932ENST00000409788Q9Y376
ENSG00000135932ENST00000409788A0A024R496
ENSG00000135932ENST00000410084Q9Y376
ENSG00000135932ENST00000410084A0A024R496
ENSG00000135932ENST00000614925A0A087X0K1

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
mTOR signallingREACTOMER-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPKREACTOMER-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377260902023CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.1
377260902023CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.1
319194062020MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.21
325279862020miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity.10
319194062020MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.21
325279862020miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity.10
307799442019MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.39
307799442019MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.39
300609502018C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25.6
301807562018MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1α/VEGF Signaling Pathway by Targeting CAB39.31
300609502018C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25.6
301807562018MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1α/VEGF Signaling Pathway by Targeting CAB39.31
286050412017Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.29
286050412017Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.29
232962032013Structural insights into the activation of MST3 by MO25.14

Citation

Dessen P

CAB39 (calcium binding protein 39)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47073/cab39