CALCOCO2 (calcium binding and coiled-coil domain 2)

2014-11-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
NDP52
FUSION GENES

Other Information

Locus ID:

NCBI: 10241
MIM: 604587
HGNC: 29912
Ensembl: ENSG00000136436

Variants:

dbSNP: 10241
ClinVar: 10241
TCGA: ENSG00000136436
COSMIC: CALCOCO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136436ENST00000258947Q13137
ENSG00000136436ENST00000416445Q13137
ENSG00000136436ENST00000448105Q13137
ENSG00000136436ENST00000502761D6RF70
ENSG00000136436ENST00000505071D6RBI4
ENSG00000136436ENST00000507076D6RBF9
ENSG00000136436ENST00000507306H0Y9G3
ENSG00000136436ENST00000508679Q13137
ENSG00000136436ENST00000509415D6RJE7
ENSG00000136436ENST00000509507Q13137
ENSG00000136436ENST00000509784H0YBP4
ENSG00000136436ENST00000513119D6REB0
ENSG00000136436ENST00000570513I3L493
ENSG00000136436ENST00000576582I3L4E1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
262669772015The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.511
198207082009The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria.356
216463502011p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways.127
230223822012LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.109
210794142011The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway.88
231433962012Selective autophagy degrades DICER and AGO2 and regulates miRNA activity.88
236241082013Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.63
147475552004Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: localization, dynamics, recruitment of ICP27, and evidence for the de novo induction of ND10-like complexes.57
257717912015Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation.47
232098072012TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling.44

Citation

Dessen P

CALCOCO2 (calcium binding and coiled-coil domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61386/calcoco2