Identity
HGNC
LOCATION
5q32
LOCUSID
ALIAS
CAMKA,CaMKIINalpha,CaMKIIalpha,MRD53,MRT63
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 815
MIM: 114078
HGNC: 1460
Ensembl: ENSG00000070808
Variants:
dbSNP: 815
ClinVar: 815
TCGA: ENSG00000070808
COSMIC: CAMK2A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA248 | NFKB1 | Gene | Pathway | associated | |||
| PA27749 | ELK1 | Gene | Pathway | associated | |||
| PA28212 | FOS | Gene | Pathway | associated | |||
| PA296 | RELA | Gene | Pathway | associated | |||
| PA30006 | JUN | Gene | Pathway | associated | |||
| PA31353 | MYC | Gene | Pathway | associated | |||
| PA31600 | NFKB2 | Gene | Pathway | associated | |||
| PA337 | STAT3 | Gene | Pathway | associated | |||
| PA338 | STAT5A | Gene | Pathway | associated | |||
| PA36042 | SP1 | Gene | Pathway | associated | |||
| PA36183 | STAT1 | Gene | Pathway | associated | |||
| PA36184 | STAT2 | Gene | Pathway | associated | |||
| PA36185 | STAT4 | Gene | Pathway | associated | |||
| PA36186 | STAT5B | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38015546 | 2023 | Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells. | 0 |
| 38015546 | 2023 | Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells. | 0 |
| 33707504 | 2021 | Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. | 8 |
| 34607601 | 2021 | Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents. | 3 |
| 34728029 | 2021 | [Dysregulation of MAD2L1/CAMK2A/PTTG1 Gene Cluster Maintains the Stemness Characteristics of Uterine Corpus Endometrial Carcinoma]. | 3 |
| 33707504 | 2021 | Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. | 8 |
| 34607601 | 2021 | Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents. | 3 |
| 34728029 | 2021 | [Dysregulation of MAD2L1/CAMK2A/PTTG1 Gene Cluster Maintains the Stemness Characteristics of Uterine Corpus Endometrial Carcinoma]. | 3 |
| 31750928 | 2020 | Regular Aerobic Exercise-Alleviated Dysregulation of CAMKIIα Carbonylation to Mitigate Parkinsonism via Homeostasis of Apoptosis With Autophagy. | 4 |
| 32149607 | 2020 | Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation. | 23 |
| 32418901 | 2020 | Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly. | 1 |
| 32483123 | 2020 | CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation. | 8 |
| 32580140 | 2020 | Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies. | 11 |
| 32611770 | 2020 | CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability. | 12 |
| 32685443 | 2020 | Role of Oxidation-Dependent CaMKII Activation in the Genesis of Abnormal Action Potentials in Atrial Cardiomyocytes: A Simulation Study. | 7 |
Citation
Dessen P
CAMK2A (calcium/calmodulin dependent protein kinase II alpha)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43181/camk2a
