CAP1 (cyclase associated actin cytoskeleton regulatory protein 1)

2009-05-01  

Identity

HGNC
CAP1
LOCATION
1p34.2
LOCUSID
10487
ALIAS
CAP,CAP1-PEN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10487
MIM: 617801
HGNC: 20040
Ensembl: ENSG00000131236

Variants:

dbSNP: 10487
ClinVar: 10487
TCGA: ENSG00000131236
COSMIC: CAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131236ENST00000340450Q01518
ENSG00000131236ENST00000372792Q01518
ENSG00000131236ENST00000372797Q01518
ENSG00000131236ENST00000372798Q01518
ENSG00000131236ENST00000372802Q01518
ENSG00000131236ENST00000372805Q01518
ENSG00000131236ENST00000414281Q5T0R2
ENSG00000131236ENST00000414893Q5T0S3
ENSG00000131236ENST00000417287Q5T0R6
ENSG00000131236ENST00000420216Q5T0R5
ENSG00000131236ENST00000421589Q5T0R3
ENSG00000131236ENST00000424977Q5T0R4
ENSG00000131236ENST00000427843Q5T0R1
ENSG00000131236ENST00000435719Q5T0R9
ENSG00000131236ENST00000446031Q5T0R8
ENSG00000131236ENST00000449311Q5T0R7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Role of Abl in Robo-Slit signalingREACTOMER-HSA-428890
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
119508782002Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover.67
246069032014Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes.55
204710302010Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.42
187162852008Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis.36
237375252013Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion.33
204160772010Identification of type 2 diabetes-associated combination of SNPs using support vector machine.26
191889112009Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility.25
238428842013Overexpression of adenylate cyclase-associated protein 1 is associated with metastasis of lung cancer.17
245228102014High expression and prognostic role of CAP1 and CtBP2 in breast carcinoma: associated with E-cadherin and cell proliferation.16
245091662014Knocking down the expression of adenylate cyclase-associated protein 1 inhibits the proliferation and migration of breast cancer cells.15

Citation

Dessen P

CAP1 (cyclase associated actin cytoskeleton regulatory protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50911/cap1