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CAP2 (cyclase associated actin cytoskeleton regulatory protein 2)

Identity

Alias (NCBI)-
HGNC (Hugo) CAP2
HGNC Previous nameCAP, adenylate cyclase-associated protein, 2 (yeast)
LocusID (NCBI) 10486
Atlas_Id 46267
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 17393595 and ends at 17557779 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAP2 (6p22.3) / CCDC28B (1p35.1)MED1 (17q12) / CAP2 (6p22.3)TEAD1 (11p15.3) / CAP2 (6p22.3)
MED1 17q12 / CAP2 6p22.3TEAD1 11p15.3 / CAP2 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;11)(p22;p15) TEAD1/CAP2
t(6;17)(p22;q12) MED1/CAP2

External links

Nomenclature
HGNC (Hugo)CAP2   20039
Cards
Entrez_Gene (NCBI)CAP2    cyclase associated actin cytoskeleton regulatory protein 2
Aliases
GeneCards (Weizmann)CAP2
Ensembl hg19 (Hinxton)ENSG00000112186 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112186 [Gene_View]  ENSG00000112186 [Sequence]  chr6:17393595-17557779 [Contig_View]  CAP2 [Vega]
ICGC DataPortalENSG00000112186
TCGA cBioPortalCAP2
AceView (NCBI)CAP2
Genatlas (Paris)CAP2
SOURCE (Princeton)CAP2
Genetics Home Reference (NIH)CAP2
Genomic and cartography
GoldenPath hg38 (UCSC)CAP2  -     chr6:17393595-17557779 +  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAP2  -     6p22.3   [Description]    (hg19-Feb_2009)
GoldenPathCAP2 - 6p22.3 [CytoView hg19]  CAP2 - 6p22.3 [CytoView hg38]
ImmunoBaseENSG00000112186
genome Data Viewer NCBICAP2 [Mapview hg19]  
OMIM618385   
Gene and transcription
Genbank (Entrez)AI928000 AK293134 AK294215 AK295600 AK297538
RefSeq transcript (Entrez)NM_001363533 NM_001363534 NM_006366
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAP2
Alternative Splicing GalleryENSG00000112186
Gene ExpressionCAP2 [ NCBI-GEO ]   CAP2 [ EBI - ARRAY_EXPRESS ]   CAP2 [ SEEK ]   CAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)CAP2 [ Firebrowse - Broad ]
GenevisibleExpression of CAP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10486
GTEX Portal (Tissue expression)CAP2
Human Protein AtlasENSG00000112186-CAP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40123   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40123  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40123
Splice isoforms : SwissVarP40123
PhosPhoSitePlusP40123
Domaine pattern : Prosite (Expaxy)C_CAP_COFACTOR_C (PS51329)    CAP_1 (PS01088)    CAP_2 (PS01089)   
Domains : Interpro (EBI)Adenylate_cyclase-assoc_CAP    Adenylate_cyclase-assoc_CAP_C    Adenylate_cyclase-assoc_CAP_N    C-CAP_CF_C-like    CAP/MinC_C    CAP2    CAP_C_sf    CAP_CS_C    CAP_CS_N    CAP_N_sf    CARP_motif   
Domain families : Pfam (Sanger)CAP_C (PF08603)    CAP_N (PF01213)   
Domain families : Pfam (NCBI)pfam08603    pfam01213   
Domain families : Smart (EMBL)CARP (SM00673)  
Conserved Domain (NCBI)CAP2
Blocks (Seattle)CAP2
SuperfamilyP40123
Human Protein Atlas [tissue]ENSG00000112186-CAP2 [tissue]
Peptide AtlasP40123
HPRD10808
IPIIPI00027342   IPI00552929   IPI00922216   IPI00922040   IPI00945601   IPI00922569   IPI00945887   IPI00946116   
Protein Interaction databases
DIP (DOE-UCLA)P40123
IntAct (EBI)P40123
BioGRIDCAP2
STRING (EMBL)CAP2
ZODIACCAP2
Ontologies - Pathways
QuickGOP40123
Ontology : AmiGOcell morphogenesis  actin binding  protein binding  plasma membrane  establishment or maintenance of cell polarity  signal transduction  activation of adenylate cyclase activity  actin polymerization or depolymerization  adenylate cyclase binding  postsynaptic density  cortical actin cytoskeleton  identical protein binding  regulation of adenylate cyclase activity  
Ontology : EGO-EBIcell morphogenesis  actin binding  protein binding  plasma membrane  establishment or maintenance of cell polarity  signal transduction  activation of adenylate cyclase activity  actin polymerization or depolymerization  adenylate cyclase binding  postsynaptic density  cortical actin cytoskeleton  identical protein binding  regulation of adenylate cyclase activity  
NDEx NetworkCAP2
Atlas of Cancer Signalling NetworkCAP2
Wikipedia pathwaysCAP2
Orthology - Evolution
OrthoDB10486
GeneTree (enSembl)ENSG00000112186
Phylogenetic Trees/Animal Genes : TreeFamCAP2
HOGENOMP40123
Homologs : HomoloGeneCAP2
Homology/Alignments : Family Browser (UCSC)CAP2
Gene fusions - Rearrangements
Fusion : MitelmanMED1/CAP2 [17q12/6p22.3]  
Fusion : MitelmanTEAD1/CAP2 [11p15.3/6p22.3]  
Fusion PortalMED1 17q12 CAP2 6p22.3 BRCA
Fusion PortalTEAD1 11p15.3 CAP2 6p22.3 BRCA
Fusion : QuiverCAP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAP2 [hg38]
dbVarCAP2
ClinVarCAP2
MonarchCAP2
1000_GenomesCAP2 
Exome Variant ServerCAP2
GNOMAD BrowserENSG00000112186
Varsome BrowserCAP2
Genomic Variants (DGV)CAP2 [DGVbeta]
DECIPHERCAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAP2 
Mutations
ICGC Data PortalCAP2 
TCGA Data PortalCAP2 
Broad Tumor PortalCAP2
OASIS PortalCAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCAP2
Mutations and Diseases : HGMDCAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAP2
DgiDB (Drug Gene Interaction Database)CAP2
DoCM (Curated mutations)CAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAP2 (select a term)
intoGenCAP2
Cancer3DCAP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618385   
Orphanet
DisGeNETCAP2
MedgenCAP2
Genetic Testing Registry CAP2
NextProtP40123 [Medical]
GENETestsCAP2
Target ValidationCAP2
Huge Navigator CAP2 [HugePedia]
ClinGenCAP2
Clinical trials, drugs, therapy
MyCancerGenomeCAP2
Protein Interactions : CTD
Pharm GKB GenePA134989437
PharosP40123
Clinical trialCAP2
Miscellaneous
canSAR (ICR)CAP2 (select the gene name)
HarmonizomeCAP2
DataMed IndexCAP2
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:08:15 CET 2021
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