CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1)

2011-11-01  

Identity

HGNC
CAPZA1
LOCATION
1p13.2
LOCUSID
829
ALIAS
CAPPA1,CAPZ,CAZ1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 829
MIM: 601580
HGNC: 1488
Ensembl: ENSG00000116489

Variants:

dbSNP: 829
ClinVar: 829
TCGA: ENSG00000116489
COSMIC: CAPZA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116489ENST00000263168P52907
ENSG00000116489ENST00000263168A0A024R0E5

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Advanced glycosylation endproduct receptor signalingREACTOMER-HSA-879415
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126900972003Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.35
183219532008Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.35
265660782015Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed end.33
124883172003V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein.27
169878102006The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.24
235459442013Prognostic value of CAPZA1 overexpression in gastric cancer.11
215665372011Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma.9
280930672017CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma.9
267644072016Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.7
301761572019CAPZA1 determines the risk of gastric carcinogenesis by inhibiting <i>Helicobacter pylori</i> CagA-degraded autophagy.5

Citation

Dessen P

CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52471/capza1