CARD6 (caspase recruitment domain family member 6)

2006-10-01  

Identity

HGNC
CARD6
LOCATION
5p13.1
LOCUSID
84674
ALIAS
CINCIN1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84674
MIM: 609986
HGNC: 16394
Ensembl: ENSG00000132357

Variants:

dbSNP: 84674
ClinVar: 84674
TCGA: ENSG00000132357
COSMIC: CARD6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132357ENST00000254691Q9BX69
ENSG00000132357ENST00000381677A0A0B4J1T5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
269762002016NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis.21
164182902006Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation.17
127757192003CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways.11
200254802010Expression of CARD6, an NF-kappaB activator, in gastric, colorectal and oesophageal cancers.7
165825882006CARD tricks: controlling the interactions of CARD6 with RICK and microtubules.5
297291912018Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal-Regulating Kinase 1.4

Citation

Dessen P

CARD6 (caspase recruitment domain family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43192/card6