Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial)

Identity

Alias_symbol (synonym)FLJ12118
Other aliasCOXPD27
cysRS
HGNC (Hugo) CARS2
LocusID (NCBI) 79587
Atlas_Id 61423
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 110641410 and ends at 110706180 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CARS2 (13q34) / OCIAD1 (4p11)GGT1 (22q11.23) / CARS2 (13q34)IRF7 (11p15.5) / CARS2 (13q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CARS2   25695
Cards
Entrez_Gene (NCBI)CARS2  79587  cysteinyl-tRNA synthetase 2, mitochondrial
AliasesCOXPD27; cysRS
GeneCards (Weizmann)CARS2
Ensembl hg19 (Hinxton)ENSG00000134905 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134905 [Gene_View]  ENSG00000134905 [Sequence]  chr13:110641410-110706180 [Contig_View]  CARS2 [Vega]
ICGC DataPortalENSG00000134905
TCGA cBioPortalCARS2
AceView (NCBI)CARS2
Genatlas (Paris)CARS2
WikiGenes79587
SOURCE (Princeton)CARS2
Genetics Home Reference (NIH)CARS2
Genomic and cartography
GoldenPath hg38 (UCSC)CARS2  -     chr13:110641410-110706180 -  13q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CARS2  -     13q34   [Description]    (hg19-Feb_2009)
GoldenPathCARS2 - 13q34 [CytoView hg19]  CARS2 - 13q34 [CytoView hg38]
ImmunoBaseENSG00000134905
Mapping of homologs : NCBICARS2 [Mapview hg19]  CARS2 [Mapview hg38]
OMIM612800   616672   
Gene and transcription
Genbank (Entrez)AB062436 AK022180 AK091992 AK092947 AK124505
RefSeq transcript (Entrez)NM_001352252 NM_001352253 NM_024537
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CARS2
Cluster EST : UnigeneHs.508725 [ NCBI ]
CGAP (NCI)Hs.508725
Alternative Splicing GalleryENSG00000134905
Gene ExpressionCARS2 [ NCBI-GEO ]   CARS2 [ EBI - ARRAY_EXPRESS ]   CARS2 [ SEEK ]   CARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)CARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79587
GTEX Portal (Tissue expression)CARS2
Human Protein AtlasENSG00000134905-CARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HA77   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HA77  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HA77
Splice isoforms : SwissVarQ9HA77
Catalytic activity : Enzyme6.1.1.16 [ Enzyme-Expasy ]   6.1.1.166.1.1.16 [ IntEnz-EBI ]   6.1.1.16 [ BRENDA ]   6.1.1.16 [ KEGG ]   
PhosPhoSitePlusQ9HA77
Domains : Interpro (EBI)Cys-tRNA-ligase    Cys-tRNA/MSH_ligase    Rossmann-like_a/b/a_fold    tRNA-synt_1_cat_dom    tRNAsynth_Ia_anticodon-bd   
Domain families : Pfam (Sanger)tRNA-synt_1e (PF01406)   
Domain families : Pfam (NCBI)pfam01406   
Conserved Domain (NCBI)CARS2
DMDM Disease mutations79587
Blocks (Seattle)CARS2
SuperfamilyQ9HA77
Human Protein Atlas [tissue]ENSG00000134905-CARS2 [tissue]
Peptide AtlasQ9HA77
HPRD07763
IPIIPI00336016   IPI01013817   IPI01009283   IPI01013788   IPI01014239   IPI01015853   
Protein Interaction databases
DIP (DOE-UCLA)Q9HA77
IntAct (EBI)Q9HA77
FunCoupENSG00000134905
BioGRIDCARS2
STRING (EMBL)CARS2
ZODIACCARS2
Ontologies - Pathways
QuickGOQ9HA77
Ontology : AmiGOcysteine-tRNA ligase activity  ATP binding  cytoplasm  mitochondrial matrix  cysteinyl-tRNA aminoacylation  metal ion binding  
Ontology : EGO-EBIcysteine-tRNA ligase activity  ATP binding  cytoplasm  mitochondrial matrix  cysteinyl-tRNA aminoacylation  metal ion binding  
Pathways : KEGGAminoacyl-tRNA biosynthesis    Cysteine metabolism   
NDEx NetworkCARS2
Atlas of Cancer Signalling NetworkCARS2
Wikipedia pathwaysCARS2
Orthology - Evolution
OrthoDB79587
GeneTree (enSembl)ENSG00000134905
Phylogenetic Trees/Animal Genes : TreeFamCARS2
HOGENOMQ9HA77
Homologs : HomoloGeneCARS2
Homology/Alignments : Family Browser (UCSC)CARS2
Gene fusions - Rearrangements
Fusion : QuiverCARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CARS2
dbVarCARS2
ClinVarCARS2
1000_GenomesCARS2 
Exome Variant ServerCARS2
ExAC (Exome Aggregation Consortium)ENSG00000134905
GNOMAD BrowserENSG00000134905
Varsome BrowserCARS2
Genetic variants : HAPMAP79587
Genomic Variants (DGV)CARS2 [DGVbeta]
DECIPHERCARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCARS2 
Mutations
ICGC Data PortalCARS2 
TCGA Data PortalCARS2 
Broad Tumor PortalCARS2
OASIS PortalCARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCARS2
Mutations and Diseases : HGMDCARS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CARS2
DgiDB (Drug Gene Interaction Database)CARS2
DoCM (Curated mutations)CARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CARS2 (select a term)
intoGenCARS2
Cancer3DCARS2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612800    616672   
Orphanet
DisGeNETCARS2
MedgenCARS2
Genetic Testing Registry CARS2
NextProtQ9HA77 [Medical]
TSGene79587
GENETestsCARS2
Target ValidationCARS2
Huge Navigator CARS2 [HugePedia]
snp3D : Map Gene to Disease79587
BioCentury BCIQCARS2
ClinGenCARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79587
Chemical/Pharm GKB GenePA162381083
Clinical trialCARS2
Miscellaneous
canSAR (ICR)CARS2 (select the gene name)
DataMed IndexCARS2
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCARS2
EVEXCARS2
GoPubMedCARS2
iHOPCARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 15:22:43 CEST 2019
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