CBLL1 (Cbl proto-oncogene like 1)

2003-12-01  

Identity

HGNC
LOCATION
7q22.3
LOCUSID
ALIAS
HAKAI,RNF188
FUSION GENES

Other Information

Locus ID:

NCBI: 79872
MIM: 606872
HGNC: 21225
Ensembl: ENSG00000105879

Variants:

dbSNP: 79872
ClinVar: 79872
TCGA: ENSG00000105879
COSMIC: CBLL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105879ENST00000222597Q75N03
ENSG00000105879ENST00000415884C9K074
ENSG00000105879ENST00000420796C9J2P9
ENSG00000105879ENST00000432748F8WEM5
ENSG00000105879ENST00000440859Q75N03

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Listeria monocytogenes entry into host cellsREACTOMER-HSA-8876384
InlA-mediated entry of Listeria monocytogenes into host cellsREACTOMER-HSA-8876493

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
212831292011Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis.44
211910162011Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication.33
222521312012Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin.26
195354582009Novel roles of hakai in cell proliferation and oncogenesis.25
232850922012miR-203 regulates cell proliferation through its influence on Hakai expression.19
206089372010Hakai acts as a coregulator of estrogen receptor alpha in breast cancer cells.8
286759302017Proteomic Analysis of the E3 Ubiquitin-Ligase Hakai Highlights a Role in Plasticity of the Cytoskeleton Dynamics and in the Proteasome System.6
250749332014Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure.4
294726342018Hakai overexpression effectively induces tumour progression and metastasis in vivo.4

Citation

Dessen P

CBLL1 (Cbl proto-oncogene like 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/935/cbll1