CBX4 (chromobox 4)

2007-04-01  

Identity

HGNC
CBX4
LOCATION
17q25.3
LOCUSID
8535
ALIAS
NBP16,PC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8535
MIM: 603079
HGNC: 1554
Ensembl: ENSG00000141582

Variants:

dbSNP: 8535
ClinVar: 8535
TCGA: ENSG00000141582
COSMIC: CBX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141582ENST00000269397O00257
ENSG00000141582ENST00000269397A0A0S2Z5B2
ENSG00000141582ENST00000448310F8WCW6
ENSG00000141582ENST00000495122I3L4F1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
220788782011ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs.251
215493102011Histone methylation by PRC2 is inhibited by active chromatin marks.238
126790402003The polycomb protein Pc2 is a SUMO E3.169
228978492012ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.169
199337002010Huntingtin facilitates polycomb repressive complex 2.63
244342142014Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity.58
160614792005Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.54
218850192011Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4.44
212825302011Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.42
170182942006Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.39

Citation

Dessen P

CBX4 (chromobox 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46645/cbx4