CCDC88A (coiled-coil domain containing 88A)

2008-07-01  

Identity

HGNC
CCDC88A
LOCATION
2p16.1
LOCUSID
55704
ALIAS
APE,GIRDIN,GIV,GRDN,HkRP1,KIAA1212,PEHO,PEHOL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55704
MIM: 609736
HGNC: 25523
Ensembl: ENSG00000115355

Variants:

dbSNP: 55704
ClinVar: 55704
TCGA: ENSG00000115355
COSMIC: CCDC88A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115355ENST00000263630Q3V6T2
ENSG00000115355ENST00000336838Q3V6T2
ENSG00000115355ENST00000412148H0Y470
ENSG00000115355ENST00000413716A0A2U3TZV9
ENSG00000115355ENST00000426576H7C2C6
ENSG00000115355ENST00000436346Q3V6T2
ENSG00000115355ENST00000444458H0Y7K3
ENSG00000115355ENST00000456975H0Y7U8
ENSG00000115355ENST00000471947A0A2R8Y5R4
ENSG00000115355ENST00000476903A0A2R8YCW0
ENSG00000115355ENST00000621814A0A087WXD9
ENSG00000115355ENST00000642200Q3V6T2
ENSG00000115355ENST00000642563A0A2R8YCU9
ENSG00000115355ENST00000642890A0A2R8YD99
ENSG00000115355ENST00000643265A0A2R8YGU1
ENSG00000115355ENST00000643375A0A2R8YDS8
ENSG00000115355ENST00000643413Q3V6T2
ENSG00000115355ENST00000643440A0A2R8Y4Z5
ENSG00000115355ENST00000644033A0A2R8Y7D9
ENSG00000115355ENST00000644193A0A2R8YFK8
ENSG00000115355ENST00000644415A0A2R8Y802
ENSG00000115355ENST00000644512A0A2R8Y7D4
ENSG00000115355ENST00000644630A0A2R8YG52
ENSG00000115355ENST00000644825A0A2R8Y562
ENSG00000115355ENST00000645031A0A2R8Y846
ENSG00000115355ENST00000645072A0A2R8Y4W8
ENSG00000115355ENST00000645168A0A2R8Y7L3
ENSG00000115355ENST00000645311A0A2R8Y4X4
ENSG00000115355ENST00000645477A0A2R8YG73
ENSG00000115355ENST00000645529A0A2R8YFV1
ENSG00000115355ENST00000645860A0A2R8Y885
ENSG00000115355ENST00000646285A0A2R8YCJ0
ENSG00000115355ENST00000646796Q3V6T2
ENSG00000115355ENST00000647098A0A2R8Y846
ENSG00000115355ENST00000647291A0A2R8Y5D7
ENSG00000115355ENST00000647341A0A2R8YD81
ENSG00000115355ENST00000647396A0A2R8Y820
ENSG00000115355ENST00000647401A0A2R8Y7B1
ENSG00000115355ENST00000647517A0A2R8Y6B2
ENSG00000115355ENST00000647547A0A2R8Y4C6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
241664092014Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.170
161392272005Akt/PKB regulates actin organization and cell motility via Girdin/APE.158
182640902008Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.99
192117842009GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.92
186631452008Activation of Galphai3 triggers cell migration via regulation of GIV.79
204629552010A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.72
157497032005Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles.65
183165932008An actin-binding protein Girdin regulates the motility of breast cancer cells.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
212093162011A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals.55

Citation

Dessen P

CCDC88A (coiled-coil domain containing 88A)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50215/ccdc88a