CCL11 (C-C motif chemokine ligand 11)

2003-05-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
SCYA11
FUSION GENES

Other Information

Locus ID:

NCBI: 6356
MIM: 601156
HGNC: 10610
Ensembl: ENSG00000172156

Variants:

dbSNP: 6356
ClinVar: 6356
TCGA: ENSG00000172156
COSMIC: CCL11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172156ENST00000305869P51671
ENSG00000172156ENST00000305869Q6I9T4

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
AsthmaKEGGko05310
Cytokine-cytokine receptor interactionKEGGhsa04060
AsthmaKEGGhsa05310
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166123307insomniaDiseaseVariantAnnotationassociatedPD29222992
PA445043Opioid-Related DisordersDiseaseClinicalAnnotation, VariantAnnotationassociatedPD29222992
PA450401methadoneChemicalClinicalAnnotation, VariantAnnotationassociatedPD29222992

References

Pubmed IDYearTitleCitations
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
189811622008Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.60
121937452002Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.59
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
192649732009Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.36
123704002002TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts.34
128842992003CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.33
160294962005Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle.30

Citation

Dessen P

CCL11 (C-C motif chemokine ligand 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/939/ccl11