CCL23 (C-C motif chemokine ligand 23)

2008-05-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
CK-BETA-8,CKb8,Ckb-8,Ckb-8-1,MIP-3,MIP3,MPIF-1,SCYA23,hmrp-2a

Other Information

Locus ID:

NCBI: 6368
MIM: 602494
HGNC: 10622
Ensembl: ENSG00000274736

Variants:

dbSNP: 6368
ClinVar: 6368
TCGA: ENSG00000274736
COSMIC: CCL23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000274736ENST00000612516P55773
ENSG00000274736ENST00000613876A0A087WV09
ENSG00000274736ENST00000615050P55773

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Formyl peptide receptors bind formyl peptides and many other ligandsREACTOMER-HSA-444473
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383251392024Delayed CCL23 response is associated with poor outcomes after cardiac arrest.0
383251392024Delayed CCL23 response is associated with poor outcomes after cardiac arrest.0
350018012022Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma.3
357507472022Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer.13
350018012022Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma.3
357507472022Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer.13
340507042021CCL23 suppresses liver cancer progression through the CCR1/AKT/ESR1 feedback loop.11
340507042021CCL23 suppresses liver cancer progression through the CCR1/AKT/ESR1 feedback loop.11
319580842020CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease.18
319580842020CCL23: A Chemokine Associated with Progression from Mild Cognitive Impairment to Alzheimer's Disease.18
318145672019[Bioinformatics analysis and significance of expression of CC chemokine ligand 23 (CCL23) in hepatocellular carcinoma].6
318145672019[Bioinformatics analysis and significance of expression of CC chemokine ligand 23 (CCL23) in hepatocellular carcinoma].6
265600432016Tissue proteases convert CCL23 into potent monocyte chemoattractants in patients with chronic rhinosinusitis.5
265600432016Tissue proteases convert CCL23 into potent monocyte chemoattractants in patients with chronic rhinosinusitis.5
243844272014Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease.5

Citation

Dessen P

CCL23 (C-C motif chemokine ligand 23)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50135/ccl23