CCL25 (C-C motif chemokine ligand 25)

2008-07-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
Ck

Other Information

Locus ID:

NCBI: 6370
MIM: 602565
HGNC: 10624
Ensembl: ENSG00000131142

Variants:

dbSNP: 6370
ClinVar: 6370
TCGA: ENSG00000131142
COSMIC: CCL25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131142ENST00000253451O15444
ENSG00000131142ENST00000315626C9JDZ7
ENSG00000131142ENST00000390669O15444
ENSG00000131142ENST00000458625F8VWI0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
333476172021CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts.10
348084972021LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25.5
333476172021CCL25 and CCR9 is a unique pathway that potentiates pannus formation by remodeling RA macrophages into mature osteoclasts.10
348084972021LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25.5
318259412020Increased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps.0
320643352020Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9(+) T cells.24
323238232020Thymus‑expressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis.3
330588522020The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes.6
318259412020Increased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps.0
320643352020Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9(+) T cells.24
323238232020Thymus‑expressed chemokine secreted by breast cancer cells promotes metastasis and inhibits apoptosis.3
330588522020The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes.6
300605612018Chemokine CCL25 Induces Migration and Extracellular Matrix Production of Anulus Fibrosus-Derived Cells.7
300605612018Chemokine CCL25 Induces Migration and Extracellular Matrix Production of Anulus Fibrosus-Derived Cells.7
264720152016Epigenetic characteristics in inflammatory candidate genes in aggressive periodontitis.19

Citation

Dessen P

CCL25 (C-C motif chemokine ligand 25)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50273/ccl25