CCL28 (C-C motif chemokine ligand 28)

2011-09-01  

Identity

HGNC
LOCATION
5p12
LOCUSID
ALIAS
CCK1,MEC,SCYA28
FUSION GENES

Other Information

Locus ID:

NCBI: 56477
MIM: 605240
HGNC: 17700
Ensembl: ENSG00000151882

Variants:

dbSNP: 56477
ClinVar: 56477
TCGA: ENSG00000151882
COSMIC: CCL28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151882ENST00000361115Q9NRJ3
ENSG00000151882ENST00000361115A0N0Q3
ENSG00000151882ENST00000489442Q9NRJ3
ENSG00000151882ENST00000489442A0N0Q3
ENSG00000151882ENST00000513525D6RC73

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217538532011Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.320
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126710492003CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.84
125387072003CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity.74
167855572006Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.53
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26
277166212016Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer.22
190039342008Human IgA-secreting cells induced by intestinal, but not systemic, immunization respond to CCL25 (TECK) and CCL28 (MEC).19

Citation

Dessen P

CCL28 (C-C motif chemokine ligand 28)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52369/ccl28