CCL8 (C-C motif chemokine ligand 8)

2003-06-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
HC14,MCP-2,MCP2,SCYA10,SCYA8
FUSION GENES

Other Information

Locus ID:

NCBI: 6355
MIM: 602283
HGNC: 10635
Ensembl: ENSG00000108700

Variants:

dbSNP: 6355
ClinVar: 6355
TCGA: ENSG00000108700
COSMIC: CCL8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108700ENST00000394620P80075

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062

References

Pubmed IDYearTitleCitations
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
186603812008Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx.77
188359322008Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes.67
186848492008Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis.54
146470582003Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection.50
201819352010CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells.46
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
188187482008Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.31
195275142009Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.31

Citation

Dessen P

CCL8 (C-C motif chemokine ligand 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/947/ccl8