CCNB2 (cyclin B2)

2003-08-01 Affiliation

Identity

HGNC

CCNB2

LOCATION

15q22.2

LOCUSID

9133

ALIAS

HsT17299

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9133
MIM: 602755
HGNC: 1580
Ensembl: ENSG00000157456

Variants:

dbSNP: 9133
ClinVar: 9133
TCGA: ENSG00000157456
COSMIC: CCNB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157456	ENST00000288207	O95067
ENSG00000157456	ENST00000559622	H0YMP3
ENSG00000157456	ENST00000621385	H1UBN3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell cycle	KEGG	ko04110
p53 signaling pathway	KEGG	ko04115
Progesterone-mediated oocyte maturation	KEGG	ko04914
Cell cycle	KEGG	hsa04110
p53 signaling pathway	KEGG	hsa04115
Progesterone-mediated oocyte maturation	KEGG	hsa04914
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
FoxO signaling pathway	KEGG	hsa04068
Cell cycle - G2/M transition	KEGG	hsa_M00693
Cell cycle - G2/M transition	KEGG	M00693
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle Checkpoints	REACTOME	R-HSA-69620
G2/M Checkpoints	REACTOME	R-HSA-69481
G2/M DNA replication checkpoint	REACTOME	R-HSA-69478
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Cyclin A/B1 associated events during G2/M transition	REACTOME	R-HSA-69273
Cyclin B2 mediated events	REACTOME	R-HSA-157881
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Polo-like kinase mediated events	REACTOME	R-HSA-156711
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Golgi Cisternae Pericentriolar Stack Reorganization	REACTOME	R-HSA-162658
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Activation of NIMA Kinases NEK9, NEK6, NEK7	REACTOME	R-HSA-2980767
Nuclear Pore Complex (NPC) Disassembly	REACTOME	R-HSA-3301854
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Condensation of Prometaphase Chromosomes	REACTOME	R-HSA-2514853
The role of GTSE1 in G2/M progression after G2 checkpoint	REACTOME	R-HSA-8852276

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20660152	2010	The roles of cyclin A2, B1, and B2 in early and late mitotic events.	61
23282137	2013	Elevated cyclin B2 expression in invasive breast carcinoma is associated with unfavorable clinical outcome.	33
17549666	2007	Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma.	28
26349989	2015	CCNB2 overexpression is a poor prognostic biomarker in Chinese NSCLC patients.	28
12482752	2003	Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.	26
27183908	2016	ISL1, a novel regulator of CCNB1, CCNB2 and c-MYC genes, promotes gastric cancer cell proliferation and tumor growth.	25
17533373	2007	Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2.	22
11960377	2002	Overexpression of B-type cyclins alters chromosomal segregation.	20
19738611	2009	Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.	17
26706119	2016	The decrease of cyclin B2 expression inhibits invasion and metastasis of bladder cancer.	16

Citation

Dessen P

CCNB2 (cyclin B2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/953/ccnb2