CCNDBP1 (cyclin D1 binding protein 1)

2007-02-01  

Identity

HGNC
CCNDBP1
LOCATION
15q15.2
LOCUSID
23582
ALIAS
DIP1,GCIP,HHM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23582
MIM: 607089
HGNC: 1587
Ensembl: ENSG00000166946

Variants:

dbSNP: 23582
ClinVar: 23582
TCGA: ENSG00000166946
COSMIC: CCNDBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166946ENST00000300213O95273
ENSG00000166946ENST00000562553H3BQA6
ENSG00000166946ENST00000563065H3BQA6
ENSG00000166946ENST00000565296O95273
ENSG00000166946ENST00000566515O95273
ENSG00000166946ENST00000567434H3BUF4
ENSG00000166946ENST00000568507H3BR23
ENSG00000166946ENST00000569745H3BUF4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
175327602007Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model.27
189234192008An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling.17
176212662008Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells.13
261071952015miR-9 Modulates Osteosarcoma Cell Growth by Targeting the GCIP Tumor Suppressor.11
204605302010A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment.7
224533382012Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.7
165016032006Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis.6
249708092014GCIP functions as a tumor suppressor in non-small cell lung cancer by suppressing Id1-mediated tumor promotion.3
189834642008Immunohistochemical expression of GCIP in breast carcinoma: relationship with tumour grade, disease-free survival, mucinous differentiation and response to chemotherapy.2
191534492009Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator.2

Citation

Dessen P

CCNDBP1 (cyclin D1 binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45933/ccndbp1