CCNE2 (cyclin E2)

2003-02-01  

Identity

HGNC
LOCATION
8q22.1
LOCUSID
ALIAS
CYCE2
FUSION GENES

Other Information

Locus ID:

NCBI: 9134
MIM: 603775
HGNC: 1590
Ensembl: ENSG00000175305

Variants:

dbSNP: 9134
ClinVar: 9134
TCGA: ENSG00000175305
COSMIC: CCNE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175305ENST00000308108O96020
ENSG00000175305ENST00000308108A0A024R9B0
ENSG00000175305ENST00000396133Q8WUE3
ENSG00000175305ENST00000519889E5RHN2
ENSG00000175305ENST00000520509O96020
ENSG00000175305ENST00000520509A0A024R9B0
ENSG00000175305ENST00000521809E5RK20
ENSG00000175305ENST00000524224H0YBQ2

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Prostate cancerKEGGko05215
Small cell lung cancerKEGGko05222
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
Pathways in cancerKEGGhsa05200
Prostate cancerKEGGhsa05215
Small cell lung cancerKEGGhsa05222
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Cell cycle - G1/S transitionKEGGhsa_M00692
Cell cycle - G1/S transitionKEGGM00692
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G1/S DNA Damage CheckpointsREACTOMER-HSA-69615
p53-Dependent G1/S DNA damage checkpointREACTOMER-HSA-69580
p53-Dependent G1 DNA Damage ResponseREACTOMER-HSA-69563
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
SCF(Skp2)-mediated degradation of p27/p21REACTOMER-HSA-187577
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesREACTOMER-HSA-69200
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestREACTOMER-HSA-6804116

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196385772009Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells.66
260574532015Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer.51
258432942015MicroRNA-30d-5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non-small cell lung cancer.46
167407532006Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients.30
195644132009Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc.27
262654402015A novel HMGA1-CCNE2-YAP axis regulates breast cancer aggressiveness.25
191072332009Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis.23
255508092014MicroRNA-25 regulates small cell lung cancer cell development and cell cycle through cyclin E2.22
241161102013The loss of miR-26a-mediated post-transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival.21
190845162009SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis.20

Citation

Dessen P

CCNE2 (cyclin E2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/957/ccne2