CCNF (cyclin F)

2003-05-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
FBX1,FBXO1,FTDALS5
FUSION GENES

Other Information

Locus ID:

NCBI: 899
MIM: 600227
HGNC: 1591
Ensembl: ENSG00000162063

Variants:

dbSNP: 899
ClinVar: 899
TCGA: ENSG00000162063
COSMIC: CCNF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162063ENST00000293968H0Y2P7
ENSG00000162063ENST00000397066P41002
ENSG00000162063ENST00000564236H3BUD3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226329672012Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.123
205960272010SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.103
270803132016CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.41
121220062002Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins.31
231821102013A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis.27
268188442016SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication.26
255579112015Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.25
277736722016Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.23
276536962016APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.19
311303632019Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.9

Citation

Dessen P

CCNF (cyclin F)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/958/ccnf