CCP110 (centriolar coiled-coil protein 110)

2014-08-01  

Identity

HGNC
LOCATION
16p12.3
LOCUSID
ALIAS
CP110,Cep110
FUSION GENES

Other Information

Locus ID:

NCBI: 9738
MIM: 609544
HGNC: 24342
Ensembl: ENSG00000103540

Variants:

dbSNP: 9738
ClinVar: 9738
TCGA: ENSG00000103540
COSMIC: CCP110

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103540ENST00000381396O43303
ENSG00000103540ENST00000396208O43303
ENSG00000103540ENST00000396212O43303
ENSG00000103540ENST00000561888I3L262
ENSG00000103540ENST00000562083H3BVH3
ENSG00000103540ENST00000565376H3BMS1

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177195452007Cep97 and CP110 suppress a cilia assembly program.165
194814582009Control of centriole length by CPAP and CP110.151
123615982002CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.119
186945592008CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.119
205960272010SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.103
216204532011Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis.86
226842562012miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.61
234860642013USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.59
167604252006CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.38
219821132011Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis.34

Citation

Dessen P

CCP110 (centriolar coiled-coil protein 110)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54205/ccp110