CCR8 (C-C motif chemokine receptor 8)

2013-11-01  

Identity

HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
CC-CKR-8,CCR-8,CDw198,CKRL1,CMKBR8,CMKBRL2,CY6,GPRCY6,TER1

Other Information

Locus ID:

NCBI: 1237
MIM: 601834
HGNC: 1609
Ensembl: ENSG00000179934

Variants:

dbSNP: 1237
ClinVar: 1237
TCGA: ENSG00000179934
COSMIC: CCR8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179934ENST00000326306P51685
ENSG00000179934ENST00000414803C9JIP9

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
158147392005CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation.48
170826092006CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes.43
239995002013Identification of human CCR8 as a CCL18 receptor.38
230430702012Epidermis instructs skin homing receptor expression in human T cells.32
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25
176410402007Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis.24
126459482003CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I.19
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
285333802017CCR8+FOXp3+ Treg cells as master drivers of immune regulation.18

Citation

Dessen P

CCR8 (C-C motif chemokine receptor 8)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53548/ccr8