Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9973
MIM: 603864
HGNC: 1613
Ensembl: ENSG00000173992
Variants:
dbSNP: 9973
ClinVar: 9973
TCGA: ENSG00000173992
COSMIC: CCS
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000173992 | ENST00000310190 | J3KNF4 |
| ENSG00000173992 | ENST00000530961 | E9PK03 |
| ENSG00000173992 | ENST00000533244 | O14618 |
| ENSG00000173992 | ENST00000534763 | E9PP76 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37924725 | 2023 | CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress. | 4 |
| 37924725 | 2023 | CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress. | 4 |
| 34715128 | 2021 | The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation. | 14 |
| 34715128 | 2021 | The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation. | 14 |
| 32121118 | 2020 | Mutations in Superoxide Dismutase 1 (Sod1) Linked to Familial Amyotrophic Lateral Sclerosis Can Disrupt High-Affinity Zinc-Binding Promoted by the Copper Chaperone for Sod1 (Ccs). | 16 |
| 32121118 | 2020 | Mutations in Superoxide Dismutase 1 (Sod1) Linked to Familial Amyotrophic Lateral Sclerosis Can Disrupt High-Affinity Zinc-Binding Promoted by the Copper Chaperone for Sod1 (Ccs). | 16 |
| 30735496 | 2019 | Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. | 25 |
| 30824611 | 2019 | Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis. | 30 |
| 30735496 | 2019 | Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS. | 25 |
| 30824611 | 2019 | Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis. | 30 |
| 29234142 | 2017 | A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants. | 26 |
| 29234142 | 2017 | A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants. | 26 |
| 26745464 | 2016 | Extended functional repertoire for human copper chaperones. | 14 |
| 26745464 | 2016 | Extended functional repertoire for human copper chaperones. | 14 |
| 25673218 | 2015 | Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro. | 8 |
Citation
Dessen P
CCS (copper chaperone for superoxide dismutase)
Atlas Genet Cytogenet Oncol Haematol. 2011-08-01
Online version: http://atlasgeneticsoncology.org/gene/52341/ccs
